Flashcards
BMS03-1024- Pharmacology of the Sympathetic Nervous System
Cards in this deck (17)
- 1What is the intervention site with the least amount of side effects?Neuromuscular junction
- 2The 5 target areas of drugs at neuroeffector junction are1. Synthesis
2. Storage
3. Release
4. Inactivating transmitters
5. Interacting with post synaptic receptor - 3Alpha-methyl tyrosine is a drug that blocks .... by.... Side effects areSynthesis of Ach
inhibiting tyrosine hydoxylase, DOPA/noradernaline
Inhibit PNS - 4Respirine is a drug that blocks the ... by.... Side effects areStorage of Ach
Blocking VMAT (normally prevents MAO metabolism of Ach)
CNS depression - 5Normally, NA activates .... to promote inhibit release of NA (-feedback) Drugs which inhibit release (eg. Chonidine) do so by... and treat .... Drugs which stimulate release like amphetamine and cocaine do so by.... and ....1. A2 receptor
2. Acting as A2 agonists, hypertension/bradycardia
3. Competing with NA to enter VMAT so NA is pushed out of cell, Blocking NA reuptake channels - 6B2 receptors stimulate ... to increase levels of... In cardiac muscle (B1) this... In smooth muscle (B2) this...Adenylyl cyclase, cAMP
Increases rate of contraction
Causes bronchodilation - 7Non-selective B receptor antagonists such as Labetalol and Carvedilo ...., leading to a ... in BPInhibit vasoconstriction/HR, leading to a fall in BP
- 8B selective drugs such as propanolol and timolol are used to treat... and ...Cardiac arrhythmia angina
Myocardial infarction - 9B1 selective drugs such as Metoprolol and Athenolol ...Inhibit increases in HR
- 10B-adrenergic receptors are coupled to... G proteinG2
- 11Alpha adrenergic receptors are coupled with .... G proteinGq
- 12Adrenergic receptors normally activate... to cause... They are located on...IP3/DAG
Vasoconstriction/secretion
Smooth muscle - 13Selective (A1) blockers such as prazosin/Dozasin ....vasoconstriction and are...Inhibit
Anti-hypertensive - 14Salbutamol is a ..... that treats....1. B2 agonist
2. Asthma/premature labour - 15Atenolol is a .... that treats ....B1 antagonist
Hypertension/angina by blocking increase in HR - 16Prazosin is a .... that treats....1. A1 antagonist
2 Hypertension by inhibiting HR increase - 17Labetalol is a .... that treats ...Non selective (A1/B) antagonist
Hypertension
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- BMS03 - Nerve Signalling Flashcards on BMS03-1024- Pharmacology of the Sympathetic Nervous System, created by Evian Chai on 30/04/2020.
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- Evian Chai
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