22447516
Description
Flashcards by Evian Chai, updated more than 1 year ago
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Created by Evian Chai
almost 4 years ago
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| Question | Answer |
| What is the intervention site with the least amount of side effects? | Neuromuscular junction |
| The 5 target areas of drugs at neuroeffector junction are | 1. Synthesis 2. Storage 3. Release 4. Inactivating transmitters 5. Interacting with post synaptic receptor |
| Alpha-methyl tyrosine is a drug that blocks .... by.... Side effects are | Synthesis of Ach inhibiting tyrosine hydoxylase, DOPA/noradernaline Inhibit PNS |
| Respirine is a drug that blocks the ... by.... Side effects are | Storage of Ach Blocking VMAT (normally prevents MAO metabolism of Ach) CNS depression |
| Normally, NA activates .... to promote inhibit release of NA (-feedback) Drugs which inhibit release (eg. Chonidine) do so by... and treat .... Drugs which stimulate release like amphetamine and cocaine do so by.... and .... | 1. A2 receptor 2. Acting as A2 agonists, hypertension/bradycardia 3. Competing with NA to enter VMAT so NA is pushed out of cell, Blocking NA reuptake channels |
| B2 receptors stimulate ... to increase levels of... In cardiac muscle (B1) this... In smooth muscle (B2) this... | Adenylyl cyclase, cAMP Increases rate of contraction Causes bronchodilation |
| Non-selective B receptor antagonists such as Labetalol and Carvedilo ...., leading to a ... in BP | Inhibit vasoconstriction/HR, leading to a fall in BP |
| B selective drugs such as propanolol and timolol are used to treat... and ... | Cardiac arrhythmia angina Myocardial infarction |
| B1 selective drugs such as Metoprolol and Athenolol ... | Inhibit increases in HR |
| B-adrenergic receptors are coupled to... G protein | G2 |
| Alpha adrenergic receptors are coupled with .... G protein | Gq |
| Adrenergic receptors normally activate... to cause... They are located on... | IP3/DAG Vasoconstriction/secretion Smooth muscle |
| Selective (A1) blockers such as prazosin/Dozasin ....vasoconstriction and are... | Inhibit Anti-hypertensive |
| Salbutamol is a ..... that treats.... | 1. B2 agonist 2. Asthma/premature labour |
| Atenolol is a .... that treats .... | B1 antagonist Hypertension/angina by blocking increase in HR |
| Prazosin is a .... that treats.... | 1. A1 antagonist 2 Hypertension by inhibiting HR increase |
| Labetalol is a .... that treats ... | Non selective (A1/B) antagonist Hypertension |
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