Pharmacological Treatments for DYSPEPSIA, GASTRITIS & PEPTIC ULCER

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Mind Map by sesamemonstersx, updated 12 months ago
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Diploma Pharmacology II Mind Map on Pharmacological Treatments for DYSPEPSIA, GASTRITIS & PEPTIC ULCER, created by sesamemonstersx on 06/25/2014.
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Pharmacological Treatments for DYSPEPSIA, GASTRITIS & PEPTIC ULCER
1 Acid Suppression
1.1 Histamine (H2) Receptor antagonist
1.1.1 MOA: Inhibits the action of Histamine ay H2 receptor on Parietal Cells
1.1.2 Administration
1.1.2.1 Twice Daily
1.1.2.2 Single dose at night for 4-8 weeks
1.1.3 Side effects
1.1.3.1 Diarrhoea
1.1.3.2 Altered Liver Function Test
1.1.3.3 Headache
1.1.3.4 Dizziness
1.1.3.5 Rash
1.1.3.6 Tiredness
1.2 Proton Pump Inhibitor
1.2.1 MOA: Inhibit H+/K+ dependent ATPasse proton pump, degreasing gastric acid secretion
1.2.1.1 Better than H2 antagonist as H2 only inhibit Histamine component, PPI inhibit the proton Pump
1.2.2 Examples
1.2.2.1 Omepraozole
1.2.2.2 Esomeprazole
1.2.3 Side Effects
1.2.3.1 GI distrbances
1.2.3.2 Headache
1.2.3.3 DIzziness
1.2.4 Caution
1.2.4.1 Gastric Cancer
1.2.4.2 Liver disease
1.2.4.3 Pregnancy & breast feeding
2 Antacids
2.1 Types
2.1.1 Magnesium
2.1.1.1 Diarrhoea
2.1.2 Aluminium
2.1.2.1 Contipation
2.1.3 Calcium
2.1.3.1 Hypercalcemia
2.2 MOA: Neutralize Gastric Activity
2.2.1 Increase In stomach and duodenal pH
2.2.2 Inactivation of pepsin
2.3 Alginate-containing
2.3.1 Forms a raft that floats on the surface of the stomach content
3 Prokinetics
3.1 MOA: Dopamine antagonist
3.1.1 Stimulate gastric emptyping & small intestinal transit
3.1.2 Enhance strength of esophageal spinchter contration
3.2 Examples
3.2.1 Metoclopramide
3.2.2 Doperidone
3.3 Side Effects
3.3.1 High blood prolactin level
3.3.2 Enlargement of breast in male
3.3.3 Abnormal production of breast milk
4 Cytoprotectives
4.1 Chelates
4.1.1 Unknown MOA
4.1.2 Examples
4.1.2.1 Tripotassium Dicitratobismuthate
4.1.2.2 Rinitidine bismuth citrate
4.2 Misoprostol
4.2.1 Uses
4.2.1.1 Older Frail People
4.2.1.2 prevention of gastric ulcer in patients requiring long tern non-steroidal or aspirin therapy
4.2.2 MOA: Antisecretory, inhibit basal & noctonal gasric acid secretion by parietal cells
4.3 Complexes
4.3.1 Sucralfate
4.3.1.1 MOA: activated by acid, forms viscous adherent gel that bind to ulcer crater
4.3.1.1.1 inhibit pepsin, absorbs bile salts
4.3.2 Side effects
4.3.2.1 Constipation, diarrhoea
4.3.2.2 Nausea
4.3.2.3 Gastric Discomfort
5 H.pylori Eradication
5.1 Recommended regimen
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