Pharmacological Treatments for DYSPEPSIA, GASTRITIS & PEPTIC ULCER

Mind Map by sesamemonstersx, updated 12 months ago
Created by sesamemonstersx over 5 years ago


Diploma Pharmacology II Mind Map on Pharmacological Treatments for DYSPEPSIA, GASTRITIS & PEPTIC ULCER, created by sesamemonstersx on 06/25/2014.

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Pharmacological Treatments for DYSPEPSIA, GASTRITIS & PEPTIC ULCER
1 Acid Suppression
1.1 Histamine (H2) Receptor antagonist
1.1.1 MOA: Inhibits the action of Histamine ay H2 receptor on Parietal Cells
1.1.2 Administration Twice Daily Single dose at night for 4-8 weeks
1.1.3 Side effects Diarrhoea Altered Liver Function Test Headache Dizziness Rash Tiredness
1.2 Proton Pump Inhibitor
1.2.1 MOA: Inhibit H+/K+ dependent ATPasse proton pump, degreasing gastric acid secretion Better than H2 antagonist as H2 only inhibit Histamine component, PPI inhibit the proton Pump
1.2.2 Examples Omepraozole Esomeprazole
1.2.3 Side Effects GI distrbances Headache DIzziness
1.2.4 Caution Gastric Cancer Liver disease Pregnancy & breast feeding
2 Antacids
2.1 Types
2.1.1 Magnesium Diarrhoea
2.1.2 Aluminium Contipation
2.1.3 Calcium Hypercalcemia
2.2 MOA: Neutralize Gastric Activity
2.2.1 Increase In stomach and duodenal pH
2.2.2 Inactivation of pepsin
2.3 Alginate-containing
2.3.1 Forms a raft that floats on the surface of the stomach content
3 Prokinetics
3.1 MOA: Dopamine antagonist
3.1.1 Stimulate gastric emptyping & small intestinal transit
3.1.2 Enhance strength of esophageal spinchter contration
3.2 Examples
3.2.1 Metoclopramide
3.2.2 Doperidone
3.3 Side Effects
3.3.1 High blood prolactin level
3.3.2 Enlargement of breast in male
3.3.3 Abnormal production of breast milk
4 Cytoprotectives
4.1 Chelates
4.1.1 Unknown MOA
4.1.2 Examples Tripotassium Dicitratobismuthate Rinitidine bismuth citrate
4.2 Misoprostol
4.2.1 Uses Older Frail People prevention of gastric ulcer in patients requiring long tern non-steroidal or aspirin therapy
4.2.2 MOA: Antisecretory, inhibit basal & noctonal gasric acid secretion by parietal cells
4.3 Complexes
4.3.1 Sucralfate MOA: activated by acid, forms viscous adherent gel that bind to ulcer crater inhibit pepsin, absorbs bile salts
4.3.2 Side effects Constipation, diarrhoea Nausea Gastric Discomfort
5 H.pylori Eradication
5.1 Recommended regimen
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