Bacterial Injury

Bacterial Injury

1. Intracellular

   • Ecoli and Shegilla with GI Epethilial
     • Stop Protein Synthesis
       • Cause cell to replicate and lyse
   • TB in Microphages
     • Block fusion of Phagosome and Lysosome
   • Rickettsia in Endothelial Cells
     • Cause Rashes = Vasculitis
     • Hepatitis, Pneumonia and Q fever
     • CNS Damag and Death: Rocky mountain Fever
   • Chlamydia
     • Female Sterility
     • Blindness

2. Extracellular

   • Secreted Proteins Exotoxins
     • Bacterial Housekeeping Enzymes
       • S. aureus
         • Proteases cause epidermal cells to lose adhesions and squamous shape to make infection spread occurs easily
       • C. Perfringens
         • Cause gas gangrene while consuming host's cell thru alpha toxin Lechtiniase
     • Exotoxin that do not benefit bacteria
       • S. pyogenes
         • Scarlet fever phagoencoded pyrogenic toxin
     • Regulatory functions
       • C. diphtheria
         • A subunit bind to B binding subunit to stop protein synthesis after accessing to host's cell - kill cell
     • Neurotoxic
       • C. botulism
       • C. tetnai
         • A subunit block a protein that has a function in Neurotransmitters release which leads to paralysis = diaphragm and chest muscle to stop functioning which lead to death

3. Host Immune response

   • Endotoxin
     • High LPS : high TNF, IL-1 IL-12
       • Septic shock
       • DIC
       • ARDS
     • Low LPS
       • Recruiting Leukocytes and activates T-cells
   • Superantigen
     • bind to T-cell which cause a storm of cytokines which cause acute toxic syndrome
       • S. aureus
       • S. pyogenes