STI's

STI's

1. SYPHILIS

   • Treponoma Pallidum
     • Gram negative
     • Axial filaments
   • Infection
     • 1. Primary
       • Chancre
       • 4-6 wks
     • 2. Secondary
       • Fever
       • Rash
       • Liver infection
       • Swollen lymph nodes
     • 3.Tertiary
       • Gumma
         • Soft granular lesion
       • Antibiotic resistance
         • Immune complexes
           • Inflammation
           • Tissue destruction
     • Congenital
       • Skin lesions
       • Deafness
       • Bone malformation
   • Diagnosis
     • Microscopy
     • Serological testing
   • Treatment
     • Chemotherapeutic
       • Salvarsan
     • Antibiotic
       • Penicillin
   • Immune evasion
     • Cell wall
   • X

2. Trends

   • Age
   • Geography
   • Sexual orientation

3. CHLAMYDIA

   • Chlamydia Trachomatis
     • Diagnosis
       • PCR
       • Immunoassays
     • Treatment
       • Doxycycline
     • Gram negative
     • Small genome
   • 2 stage life cycle
     • Reticulate body
       • Replication
     • Elementary body
       • Infection
     • Cell cycle
       • 1.Attachment
         • OmpA binds heparan sulphate
       • 2.Entry
         • T3SS injects TARP
           • Induces uptake
       • 3.Primary differentiation
         • EB to RB
       • 4.Cell division
         • Rapid multiplication
       • 5.Effector secretion
         • CPAF
           • Degrade host TF's
         • Chronic inflammatory response
       • 6.Secondary differentiation
         • RB to EB (Intermediate form)
         • Chromosomal condensation
         • OMC formation
         • T3SS formation
       • 7.EB release
   • symptoms

4. GONORRHOEAE

   • Neisseria Gonorrhoeae
     • Gram negative
   • Diagnosis
     • Thayer Martin agar
       • Vancomcin, inhibits gram positive Colistin, inhibits most gram neg
     • PCR
   • Treatment
     • 3rd gen cephalosporins
   • Virulence mechanisms
     • Attachment pili
     • Tight attachments
     • Change surface proteins
       • Recombination
         • Transformation
         • Gene exchange
       • Antigenic variation
         • Abberant recombination
       • Sialylated lipopolysaccharide
         • Resistant to complement and antibodies
         • Mimics host cell surface
   • Symptoms

5. Anatomy of FRT

Images and files in the map