4219564
Description
Mind Map by Atika Subari, updated more than 1 year ago
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Created by Atika Subari
over 8 years ago
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Immunology
- first line of defense : External physical barrier
- secod line : internal barriers
- third line : specific immune responses
- humoral immunity
- protection through antibodies
- antigen binding sites -> epitopes -> function -> give protection
- blocks attachment of toxins
- blocks adhesion of bacteria
- blocks adhesion of viruses
- neutralisation of toxin
- agglutination
- opsonisation
- activation of complement
- antibody-dependent cell mediated cytotoxicity
- antigen binding sites -> epitopes -> function -> give protection
- cell mediated immunity
- overcome by :
- CD8 cytotoxic T cell
- granule exocytosis
- recognition and binding of target cells -> delivery of lethal hit -> death of target cells -> recycling of cytotoxic T cells
- -granule contain - perforin & serine proteases
- recognition and binding of target cells -> delivery of lethal hit -> death of target cells -> recycling of cytotoxic T cells
- fas pathway
- Binding of TcR and antigen
- granule exocytosis
- triggers expression fas-ligand on Tc cell
- Fas on target cell cross-linked with fas-L
- APOPTOSIS
- APOPTOSIS
- Fas on target cell cross-linked with fas-L
- triggers expression fas-ligand on Tc cell
- granule exocytosis
- Binding of TcR and antigen
- granule exocytosis
- Delayed-type hypersensitivity response
- recruit monocytes
- keep macrophages at site of infection
- activate the monocytes and macrophage
- 1.Activation of CD4 T cells
- 2. Migration of effector Th cells
- 3. Recruitment and retention of monocytes
- Activation of macrophage
- 5. Elimination of pathogens in DTH reactions
- 5. Elimination of pathogens in DTH reactions
- Activation of macrophage
- 3. Recruitment and retention of monocytes
- 2. Migration of effector Th cells
- recruit monocytes
- CD8 cytotoxic T cell
- overcome by :
- protection through antibodies
- acquired immunity
- involves lymphocytes
- lymphocyte B
- B cell
- T cell
- CD4 surface protein
- TH1 cells
- TH2 cells
- TH1 cells
- CD8 surface protein
- Tc cells
- Tc cells
- CD4 surface protein
- lymphocyte B
- humoral immunity
- Organs of immune system
- primary lymphoid organs
- production sites
- maturation sites (absence of antigen)
- production sites
- secondary lymphoid organs
- maturation sites - antigen-driven immune cells
- maturation sites - antigen-driven immune cells
- primary lymphoid organs
- non-specific immune responses
- internal innate immunity
- 2nd line defense
- mechanisms protection
- physiological barrier
- phagocytosis
- inflammation
- physiological barrier
- 2nd line defense
- external innate immunity
- 1st line defense
- prevent penetration of pathogens into tissue
- 1st line defense
- internal innate immunity
- Antigen
- trigger specific immune response & react with product of responses
- Antigenic determinants sites
- carrier - antigen itself
- trigger specific immune response & react with product of responses
- Antibody
- combine with antigenic determinants
- important components for specific immune responses
- Basic structure : Y
- 2 Light chain (L) & 2 heavy chain (H)
- classes
- IgA
- IgG
- IgM
- IgD
- IgE
- IgA
- combine with antigenic determinants
- mechanism of antibody production
- APC ingest antigen -> present to TH1 cells -> IL2 released -> stimulate proliferation and differentiation of TH cell into TH2 cells
- secrete cytokines -> stimulte B cells -> antigen specific B-cell clone produced
- differentiation
- plasma cells (short-lived 1 week)
- antibody secreted
- antibody secreted
- memory cells (long-lifetime)
- plasma cells (short-lived 1 week)
- differentiation
- secrete cytokines -> stimulte B cells -> antigen specific B-cell clone produced
- APC ingest antigen -> present to TH1 cells -> IL2 released -> stimulate proliferation and differentiation of TH cell into TH2 cells
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