null
US
Sign In
Sign Up for Free
Sign Up
We have detected that Javascript is not enabled in your browser. The dynamic nature of our site means that Javascript must be enabled to function properly. Please read our
terms and conditions
for more information.
Next up
Copy and Edit
You need to log in to complete this action!
Register for Free
451578
Breast
Description
Mind Map on Breast, created by Jodie Nadal on 12/21/2013.
Mind Map by
Jodie Nadal
, updated more than 1 year ago
More
Less
Created by
Jodie Nadal
about 11 years ago
26
0
0
Resource summary
Breast
Presentation
Breast lump
most common
single or multiple
2 layers of cells
outer
myoepitheliae
inner
epithelial
Nipple discharge
milk/blood
Nipple inversion
exsema
Erosion
Pain, skin changes
most common presentation
good prognosis
cosmotic
Benign
Duct ectasia
dilated ducts
secretions & cellular debris
presentation of nipple discharge/mass
parous perimenopausal women
fibrosis
nipple retraction
symptoms may mimic cancer
calcification on mammography
smoking
Fat necrosis
trauma (~40%)
surgery
RT
hard irregular painless mass
mimics cancer
clinically and mammography
obese
after menopausal
Inflammatory
Acute pyogenic mastitis
1st few weeks of lactation
bacteria infection
S. aureus
abscess
Tuberculous mastitis
rare in western countries
firm fibrocaseous mass
mimicry
Actinomyces
rare, primary infection
abscess beneath nipple
Lymphocytic mastitis
occurs in diabetic women
autoimmune diseases
predispose to lymphoma
Granulomatous mastitis
granulomatous inflammatory infiltrate around lobules
aetiology unknown
TB has to be excluded
Screening
50-70yrs
GP/surgeon
biopsy immediately
Malignant
risk factors
>99% of BC occur in females
genetic predispostion
rare under 25yrs
overexpression of oestrogen
underexpression of progesterone
prolonged breast feeding decreases risk
high alcohol intake, smoking
increased incidence in developed countries
most common female cancer
2nd most common death
35-55yrs
average 62yrs
increased with age
Ductal carcinoma in situ
40-60yrs
2-100mm in size
90% of DCIS by mammogram
calcifications
necrosis
increased Ca2+
5% as a palpable lump
relationship to invasive carcinoma
morphological & molecular similarities to invasive
high freq. of progression to invasive carcinoma if incompletely excised
classification
grade
low/intermediate/high/mixed nuclear
pattern
cribriform/micropapillary/solid
presence of necrosis
increased chance of cancer
Lobular carcinoma in situ
Premenopausal women
no palpable lump
~20% of patients with LCIS with develop
risk is less than ADH
Invasive Carcinoma of Breast
local control
surgery
+/- radio
ability to metastasis
systematic theraoy
homone
chemo
targeted
data set
tumour size
lymph node stage
vascular invasion
hormone receptor & HER2 status
histologic types & prognosis
Additional Prognostic and Predictive factors
vascular invasion
angiogenesis
tumour necrosis, fibrosis & central scar
age, menopausal status
HER2
cell death markers
adhesion markers
tumour suppression
excellent
tubular
cribriform
low grade mucinous
moderate
lobular
medulaary
neuroendocrine
poor
ductal NST
metaplastic
Miscellaneous tumours
malignant phyllodes
lymphoma
metastasis
angiosarcoma
young women
very rare
staging
TNM
Tx,Tis,T0-4
N0-3
M0-3
NPI
size
grade
spread to lymph nodes
<4
good outcome
4.01-5.4
intermideate
>5.4
poor
stage I-IV
Lymph Node stage
examined histologically
reports
total no. of nodes
no involved
therapy type & dose determined
presence of extracapsular
higher nodes=poor
metastasis
isolated tumour cells
micrometastasis
0.2-2mm
macrometastasis
>2mm
Show full summary
Hide full summary
Want to create your own
Mind Maps
for
free
with GoConqr?
Learn more
.
Similar
Breast Anatomy & Histology
Matthew Coulson
Breast Pathology II
Matthew Coulson
Thorax Anatomy
Hannah Tribe
Surgery and Reconstruction for Breast Cancer
Matthew Coulson
Breast Pathology I
Matthew Coulson
Breast, pectoral, and axillary region
Christopher Schneider
Anatomy and Lymphatic Drainage of the breast
O GA
PHAR 5902 Breast Cancer
Jennifer Melissa Whyte
Thorax Anatomy
Esther Akinola
Breast Oncology and Palliative Care
Matthew Coulson
Cancer cell cycle and proliferation
Mrm Unicorn
Browse Library