Outline

Outline

1. Introduction

   • Theoretical framework
     • Outcomes
       • pregnancy complications
       • congenital abormalities
       • links to adult disease
         • Clinical Factors
           • Confounders
             • Long-term outcome data collection
               • Ethics
                 • Conclusion
             • “Precious baby” effect
             • Role of prognosis-based patient selection
             • Subfertility (prognosis: causes, type, & duration)
               • Previous IVF attempts
             • Socio-demographic characteristics
             • Maternal/Paternal age
             • Parity
             • eight/weight/BMI/ethnicity
             • Changes in standard protocols over time
           • current solutions
             • SET vs, DET & TET
           • stress on embryo
           • morphology
             • embryo development rate
           • culture media
           • fresh ET
             • endometrial environment
             • placental function
           • frozen ET
             • embryo quality
             • extent of manipulation
             • cryopreservation
             • duration of culture
               • EeCBlast Stage
       • BW
       • multiples
       • PTD
       • SGA
       • metabolic profile
       • Adiposity
       • CVD
       • diabetes
       • growth trajectory
       • puberty/infertility
     • DOHaD
     • fetal programming of adult disease
     • dutch famine
     • animal models
   • prevalence of ART
   • understanding of procedures

2. Main goals

3. article selection

4. Key questions