74568
Description
Mind Map by minicheddars, updated more than 1 year ago
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Created by minicheddars
almost 12 years ago
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Glycolysis
- Stage 1
- Requires 2 ATP
- Traps and destabilises glucose
- Forms 2x 3C
- Forms 2x 3C
- Requires 2 ATP
- Stage 2
- Generates 4 ATP
- oxidises to pyruvate
- Generates 4 ATP
- Stage 1 Step 1
- Trap glucose
- Enters cells via facilitated diffusion
- Through transporters
- GLUT 3
- Brain, nerve tissue
- Low Km - constant uptake
- Brain, nerve tissue
- GLUT 2
- Liver, Beta cells in pancreas
- High Km - proportional uptake
- Liver, Beta cells in pancreas
- GLUT 4
- Muscle and adipocytes
- Muscle and adipocytes
- GLUT 3
- Through transporters
- Phosphorylated
- Negatively charged so cannot diffuse out
- Hexokinase
- induced fit model
- feedback inhibition
- Effectively irreversible
- induced fit model
- Negatively charged so cannot diffuse out
- Enters cells via facilitated diffusion
- Stage 1 Step 2
- Form Fructose 6-Phosphate
- isomerisation
- By enzyme phosphoglucose isomerase
- isomerisation
- Stage 1 Step 3
- phosphorylation
- Phosphofructokinase
- sets the pace of glycolysis
- inhibited by ATP, Citrate and H+ ions
- Stimulated by AMP, ADP and fruc 2,6 bisphosphate
- sets the pace of glycolysis
- Phosphofructokinase
- phosphorylation
- Form Fructose 6-Phosphate
- Trap glucose
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