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Mind map

Arthropod infections

Pip Barton Infection English

Mind map about Arthropod infections: Yersinia Pestis, Borrelia Burgdorferi, and Lyme disease

Mind map: Arthropod infections

Map content

Arthropod infections

Yersinia Pestis
- Background
  - Plague
    - Clinical Types
      - Bubonic
        enlarged lymph node buboes
        Not easily transmitted
      - Pneumonic
        Haemorrhagic bronchopneumonia
        Highly infectious
    - Diagnosis
      - culture buboes
    - Treatment
      - Antibiotic
        Tetracycline
        Streptomycin
- Adhesins
  - Invasin
    - Binds B1 integrin induces zipper uptake
  - YadA adhesin
    - Binds collagen & mucus
- Effectors
  - 29 Ysc proteins
    - type III injectosome
  - 12 Yop proteins
    - Yop H
      - Dephoshorylates FAK and SKAP-HOM
        Inteferes with signal transduction
      - Blocks macrophage recruitment
    - Yop E
    - Yop T
      - activate Rho proteins
        depolymerises actin
        cell rounding
    - Yop P/J
      - Blocks apoptosis and block inflammatory signalling
        Block Erk Map kinase pathway
        Block lymphocyte prolif.
    - Pass through injectosome
Borrelia Burgdorferi
- Lyme disease
  - Symptoms
    - Stages 1-3
      - 1.acute phase
        Ring and rash
      - 2. weeks - mnths
        Neuritis & arthritis
      - 3. Yrs
        demyelination
  - Diagnosis
    - Culture
    - PCR
    - Serological testing
- Genome
  - Rapid lipoprotein evolution
    - Immune evasion
  - Outer surface proteins
    - Osp
      - OspA
      - OspC
    - Antigenically variable
      - Changes in environment
        Temp/Ph/etc
- Treatment
  - Penicillin/tetracycline

Information

Description: Infection Mind Map on Arthropod infections, created by Pip Barton on 18/05/2013.
Created by: Pip Barton
Views: 20
Tags: infection
History: Created by sam.hilton · May 18, 2013

Copied by Pip Barton · May 18, 2013
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