Quiz
MO15 Quality Control I
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Perguntas do quiz (8)
1Within a [blank_start]pharmacopoeia[blank_end], each product has a [blank_start]monograph[blank_end] containing information and tests used to define its quality. The monograph provides information to satisfy 3 main objectives:
1. verification of [blank_start]identity[blank_end]
2. [blank_start]homogeneity[blank_end] (to ensure absence of specified impurities)
3. [blank_start]purity[blank_end] (using assay methods)- Apharmacopoeia
- Bmonograph
- Cidentity
- Dhomogeneity
- Epurity
2Which test is not as useful to identify drugs?
- AProton (1H) or carbon (13C) NMR spectroscopy
- BMass spectrometry (MS)
- CInfrared Spectroscopy (IR)
- DUV-Vis spectroscopy
3Testing for impurities assures [blank_start]homogeneity[blank_end]. These are also called limit tests, and include:
- Testing for residual solvents — using [blank_start]gas chromatography[blank_end]
- Testing for inorganic compounds — measured by [blank_start]“residue on ignition”[blank_end]
- Testing for heavy metals — by reaction with [blank_start]thioacetamideglycerin TS (test solution)[blank_end]- Ahomogeneity
- Bpurity
- Cgas chromatography
- D“residue on ignition”
- Ethioacetamideglycerin TS (test solution)
4Which of these is not an assay method for purity?
- ATitration
- BUV-Vis spectrophotometric assay
- CHigh Performance Liquid Chromatography (HPLC)
- DThin-layer chromatography (TLC)
5Absorption of IR radiation by molecules (including drugs) result in [blank_start]vibrations[blank_end] of the chemical bonds. The simplest type of vibration is [blank_start]stretching[blank_end]. The frequency of oscillation ([blank_start]v[blank_end]) is governed by:
1) The mass of the two atoms ([blank_start]m1 and m2[blank_end])
2) The bond order (bond strength [[blank_start]springiness - K[blank_end]]), which is determined by the [blank_start]hybridisation[blank_end] of the atoms constituting the bond.- Avibrations
- Bstretching
- Cv
- Dm1 and m2
- Espringiness - K
- Fhybridisation
6There is no IR absorption by N2 or O2.
- AVerdadeiro
- BFalso
7Which of these is not an effect of conjugation?
- AIncreased resonance
- BDouble bond is shorter and weaker than expected
- CDecreased K, therefore decreased wavenumber
8Halogens shift bands to lower frequencies through induction.
- AVerdadeiro
- BFalso
Informações
- Descrição
- PHCY211 (Molecules) Quiz sobre MO15 Quality Control I, criado por Mer Scott em 13-04-2018.
- Autor
- Mer Scott
- Idioma
- English
- Visualizações
- 9
- Etiquetas
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