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Quiz

MO17 Stability of Large Molecules

Mer Scott 5 perguntas Atualizado em 13 abr 2018

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Perguntas do quiz (5)

  1. 1Select all the degradation issues that are non-covalent.
    1. ADenaturation
    2. BAggregation
    3. CAdsorption
    4. DPrecipitation
    5. EDeamidation
    6. FOxidation
    7. GGlycosylation
  2. 2Choose the incorrect statement about aggregation, the formation of macromolecular complexes.
    1. AIt is noncovalent.
    2. BIt is irreversible.
    3. CIt happens via hydrophobic association.
    4. DIt is immunogenic.
    5. EIt does not affecting binding or activity.
    6. FIt could happen because of different interfaces in production, mechanical stress, interaction with metal surfaces or in the presence of other molecules
  3. 3Choose the incorrect statement about oxidation.
    1. AIt is covalent degradation.
    2. BIt occurs on multiple amino acid side chains due to oxygen, light, or peroxide
    3. CIt impacts stability, activity and immunogenicity
    4. DThe most susceptible amino acids are methionine, cysteine, tyrosine, tryptophan, and histidine
  4. 4Deamidation is a [blank_start]covalent[blank_end] degradation which happens to [blank_start]asparagine[blank_end] (Asn) and [blank_start]g;utamine[blank_end] (Gln), removing the amino group. This results in [blank_start]aspartic acid[blank_end] (Asp) and [blank_start]glutamic acid[blank_end] (Glu) respectively, and [blank_start]decreases[blank_end] the activity of the proteins.
    1. Acovalent
    2. Bnon-covalent
    3. Casparagine
    4. Dglutamine
    5. Easpartic acid
    6. Fglutamic acid
    7. Gdecreases
    8. Hincreases
  5. 5Proteolysis is a form of [blank_start]covalent[blank_end] degradation where [blank_start]proteins[blank_end] are fragmented by [blank_start]proteases[blank_end]. In acidic solutions, [blank_start]aspartic acid (Asp)[blank_end] residues are the most susceptible to hydrolysis.
    1. Acovalent
    2. Bnon-covalent
    3. Cproteases
    4. Dproteins
    5. Easpartic acid (Asp)
    6. Fglutamic acid (Glu)

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Descrição
PHCY211 (Molecules) Quiz sobre MO17 Stability of Large Molecules, criado por Mer Scott em 13-04-2018.
Idioma
English
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12
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Criado em 13 abr 2018 · atualizado em 13 abr 2018
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