Flashcards
Nuclear Signalling by Ras
Flashcards do conjunto (14)
- 1No of Types of Raf3- A,B & C
- 2Most important form of RafB-Raf
- 3Mutation making Raf an oncogeneVal-Glutamine
- 414-3-3- FamilyInteract with phospho-serine by forming heterodimers
- 514-3-3 Binding on B-RafSer-259 & Ser 691
- 6Dephosphorylation of Ser... once recruited to membraneSer 259
- 7Membrane Associated KinasesPhosphorylate Raf to activate it
- 8Cytosolic KinasesRephosphorylate Ser259 when Raf is removed from the membrane
- 9Activation of MekPhosphorylation on Serine/Threonine
- 10CD Domain of ErkTEY sequence (T & Y phosphorylated by MEK)
- 11Once phosphorylated, Erk...Signals the nucleus (including phosphorylation of TCF/ELK1)
- 12Does ERK enter the nucleus?Yes
- 13p90rskActivated by ERK & enters nucleus
- 14NF(Kappa)B ActivationReleases transcription factor to enter nucleus
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- Year 2 FlashCards sobre Nuclear Signalling by Ras, criado por gina_evans0312 em 02-12-2013.
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- gina_evans0312
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