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Quiz

MO27 Enzymes as Drug Targets

Mer Scott 3 perguntas

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Perguntas do quiz (3)

  1. 1Which of these is not a function of enzymes?
    1. AProvides hydrophobic environment - desolvated
    2. BProvides acid/base catalysis
    3. CWeakens bonds
    4. DBrings reactants together, correctly positioned
    5. EProvides a reaction surface (active site)
    6. FProvides a hydrophilic environment - solvated
  2. 2Which of these is not a good drug target for reducing growth of or killing pathogens?
    1. ANeuraminidase
    2. BTranspeptidase
    3. CHIV protease
    4. DCyclooxygenase
  3. 3Types of competitors:
    1. Competitive inhibitors — bind to the [blank_start]same active site[blank_end], bind [blank_start]reversibly[blank_end], “If concentration of substrate increases it [blank_start]competes more effectively with[blank_end] the drug
    1.a. Transition-state inhibitors (competitive) — inhibitor that [blank_start]mimics[blank_end] the “transition state” of an enzyme catalysed reaction, need to understand the [blank_start]mechanism[blank_end] of catalysis (i.e. need to know intermediates of the reaction) to design, inhibitor should bind [blank_start]more strongly[blank_end] than either substrate or product
    2. Allosteric non-competitive inhibitors — inhibitors bind [blank_start]reversibly or irreversibly[blank_end] to the allosteric site, some enzymes can be [blank_start]naturally[blank_end] regulated by allosteric binding, can cause an [blank_start]induced[blank_end] fit or [blank_start]conformational (shape)[blank_end] change in the active site and [blank_start]reduce[blank_end] substrate affinity for it
    3. Allosteric un-competitive inhibitors — not common, bind reversibly to an enzyme when the substrate is [blank_start]already[blank_end] bound (binds to the Enzyme-Substrate (ES) complex), increasing substrate concentration [blank_start]will not[blank_end] overcome inhibition
    4. Suicide inhibitors — Kill the enzyme
    1. Asame active site
    2. Breversibly
    3. Ccompetes more effectively with
    4. Dmimics
    5. Emechanism
    6. Fmore strongly
    7. Greversibly or irreversibly
    8. Hnaturally
    9. Iinduced
    10. Jconformational (shape)
    11. Kreduce
    12. Lalready
    13. Mwill not

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Descrição
PHCY211 (Molecules) Quiz sobre MO27 Enzymes as Drug Targets, criado por Mer Scott em 15-04-2018.
Idioma
English
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