Quiz
Pharmacology I: Final Quiz
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Perguntas do quiz (158)
11. MUSCLE RELAXANTS: True or false: guaifenesin selectively depresses transmission at internuncial neurons in the spinal cord, brainstem, and subcortical areas
- AVerdadeiro
- BFalso
2Which is not an effect of guaifenesin?
- ADepresses CNS giving sedation and muscle relaxation
- BDecrease BP which then returns to normal
- CHigh doses can cause respiratory depression
- DAnalgesia
3Which of the following is false regarding guaifenesin?
- AIt has hepatic metabolism to a glucuronide and is excreted in urine
- BYou should avoid using it with physostigmine
- CIt lasts longer in female ponies than males
- DIt can cause hemolysis in cows
4Which muscle relaxant requires artificial ventilation with use?
- AGuaifenesin
- BNeuromuscular blockers
- CThat’s it…
5Which type of neuromuscular block are agonists at the ACh receptor?
- ADepolarizing
- BNon-depolarizing
6Which non-depolarizing neuromuscular blockers are incorrectly matched with their duration
- AMivacurium—short
- BTubocurarine, doxacurium, pancuronium, pipecuronium—long
- C Atracurium, rocurium, vecuronium—intermediate
- DAll of the above are correct!
7Which of the following causes initial muscle fasciculation?
- ADepolarizing neuromuscular blockers
- BNon-depolarizing neuromuscular blockers
8Which of the following are competitive antagonists at the ACh nicotinic receptor?
- ADepolarizing neuromuscular blockers
- BNon-depolarizing neuromuscular blockers
9Which of the following is not a depolarizing neuromuscular blocker?
- ADecamethonium
- BSuxamethonium
- CMivacurium
10On which of the following can you use anticholinesterase drugs to remove the effect?
- ADepolarizing neuromuscular blockers
- BNon-depolarizing neuromuscular blockers
11True or false: the amount of fasciculation correlates with the post-operative muscle pain
- AVerdadeiro
- BFalso
12Which of the following is not an effect of suxamethonium?
- ADecreased intraocular pressure
- BPotassium release
- CBradycardia
- DProlonged paralysis
- ESometimes malignant hyperthermia
13Which of the following does not influence the effect of muscle relaxants?
- AOther neuromuscular agents
- BCholinesterase inhibitors
- CAminoglycoside antibiotics
- DNone of the above
14Which of the following is the most sensitive to neuromuscular blockers?
- ADogs
- BCats
- CCattle
- DSheep
15In which species do you most commonly use neuromuscular blockers?
- APigs and cats
- BDogs and horses
- CCattle and sheep
- DHorses and cats
16HEMOSTATIC AND ANTICOAGULANTS: Which of the following hemostatics can cause extensive intravascular clotting when administered intravenously?
- AFibrinogen
- BThromboplastin
- CThrombin
- DFibrin
17What’s a good characteristic of a topical hemostatic?
- AMinimal tissue reactivity
- BEasy to sterilize and handle
- CConsist of either thrombin or collagen
- DAll of the above
18Which is used in measurement of prothrombin time during anticoagulant therapy?
- AFibrinogen
- BThromboplastin
- CThrombin
- DFibrin
19Which topical hemostatic converts endogenous fibrinogen to fibrin for clot formation?
- AFibrinogen
- BThromboplastin
- CThrombin
- DFibrin
20Which topical hemostatic can be used for bleeding from denuded mucous membranes, as an adhesive in skin grafts, and for massive blood loss?
- AFibrinogen
- BThromboplastin
- CThrombin
- DFibrin
21Which topical hemostatic is used for bleeding from parenchymatous tissue, cancellous bone, dental sockets, laryngeal/nasal surgery, reconstructive surgery, and as an adhesive agent for fixation of skin grafts?
- AFibrinogen
- BThromboplastin
- CThrombin
- DFibrin
22Is fibrin foam soluble?
- AYes
- BNo
23What do you use absorbable gelatin sponge/gelfoam for?
- AOozing from the surface area
- BMassive blood loss
- CCapillary/venous bleeding
- DSurgery of the liver and spleen
24Which of the following should only be used temporarily because otherwise you’d get fractures and cysts?
- AOxidized cellulose
- BGelatin sponge
- CMicrocrystalline collagen
- DStyptics
25Which are clinical uses of microcrystalline collagen?
- AClotting factor deficiencies
- BThrombocytopenia
- CSurgery of the liver and spleen
- DClotting factor deficiencies and Thrombocytopenia
- EClotting factor deficiencies and Surgery of the liver and spleen
- FThrombocytopenia and Surgery of the liver and spleen
26Which topical hemostatic produces immediate vasoconstriction and controls bleeding from small vessels?
- AOxidized cellulose
- BGelatin sponge
- CMicrocrystalline collagen
- DEpinephrine
27What’s the problem with high concentrations of styptics?
- ACyst formation
- BFractures
- CSloughing of tissues and hemorrhage
- DReduced effectiveness
28Which systemic hemostatic is used for emergency treatment of acute hemorrhagic syndromes with deficiency of clotting factors/platelets?
- AVitamin K
- BBlood
- CDesmopressin acetate
- DProtamine sulfate
29Which systemic hemostatic releases stored vWf from endothelial cell and macrophages and controls capillary bleeding from wounds?
- AVitamin K
- BBlood
- CDesmopressin acetate
- DProtamine sulfate
30Which systemic hemostatic is made from fish sperm?
- AVitamin K
- BBlood
- CDesmopressin acetate
- DProtamine sulfate
31Which systemic hemostatic is used to antagonize heparin-induced hemorrhagic action (since it’s basic and combines with the acidic heparin to prevent it from acting as an anticoagulant)?
- AVitamin K
- BBlood
- CDesmopressin acetate
- DProtamine sulfate
32Which systemic hemostatic aids in the production of clotting factors II, VII, IX, and X and should not be given IM or IV?
- AVitamin K
- BBlood
- CDesmopressin acetate
- DProtamine sulfate
33Repeated administration of which drug reduces its effectiveness?
- AVitamin K
- BBlood
- CDesmopressin acetate
- DProtamine sulfate
34Which anticoagulant should you not use for laboratory diagnostic purposes?
- ASodium oxalate
- BAcid citrate dextrose
- CSodium citrate
- DEdetate disodium
35Which is not part of the mechanism of heparin?
- ABinds reversibly to antithrombin III to produce conformational changes to it, thereby inhibiting thrombin and activated factor Xa
- BBinds to endothelial walls, imparts negative charge, inhibits platelet adhesion and aggregation
- CInhibits hepatic synthesis of prothrombin and factors II, VII, IX, and X
- DIncreases plasminogen activator and tissue factor inhibitor
36Which of these describes the action of heparin?
- AAntithrombotic
- BAnticoagulatory
- CNeither
- DBoth
37Which of the following statements is false regarding heparin?
- AIt’s used to prevent venous thrombosis and pulmonary embolism, and to treat thromboemboli, as well as to treat DIC and to decrease risk factors in heartworm
adulticide treatment - BIt prevents serosal post-operative adhesions
- CIt’s metabolized by the liver and reticulo endothelial system
- DIts antidotes are protamine and fresh blood
- AIt’s used to prevent venous thrombosis and pulmonary embolism, and to treat thromboemboli, as well as to treat DIC and to decrease risk factors in heartworm
38Which of the following is false regarding vitamin K antagonists?
- AIt is stored in adipose tissue
- BUndergoes metabolism in the liver and is excreted in urine
- CIt’s used for prophylaxis and treatment of venous thrombosis
- DIts side effect is hemorrhage
39Which of the following is false regarding fibrinolytic agents?
- AStreptokinase can cause systemic fibrinolysis
- BTissue plasminogen activator is used for lysis of aortic thromboemboli in cats
- CFibrinolysin is an activator of plasminogen
- DUrokinase is isolated from pee and prevents serosal post-operative adhesions in dogs
40Which of the following irreversibly binds COX in order to inhibit thromboxane A2 and prostaglandins?
- AAspirin
- BClopidogrel
- CDipyrimadole
- DTiclopridine
41Which of the following inhibits phosphodiesterase, increasing cAMP levels in platelets, which inhibits aggregation?
- AAspirin
- BClopidogrel
- CDipyrimadole
- DTiclopidine
42Which of the following is a P2Y12 receptor inhibitor, resulting in more cAMP and less aggregation of platelets?
- AAspirin
- BDipyrimadole
- CTiclopidine
43ANTICONVULSANTS: True or false: seizures are associated with episodic high frequency discharge of impulses by a group of neurons
- AVerdadeiro
- BFalso
44Which of the following neurotransmitters is not involved in epileptogenesis?
- AGlutamate
- BAspartate
- CGlycine
- DGABA
45Which of the following is a problem associated with seizures?
- ABrain edema
- BHyperthermia
- CAspiration pneumonia
- DDisseminated intravascular coagulation
- EPermanent brain injury
- FAll of the above
46Which is not a drug used in emergency treatment of seizures that stimulates GABA?
- APhenytoin
- BBarbiturates
- CBenzodiazepines
- DValproate
47Which of the following drugs is mismatched with its mechanism of action?
- ACarbamazepine—inhibition of Na channels
- BZonisamide—inhibition of Ca channels
- CPropofol—inhibition of Ca channels
- DPhenytoin—inhibition of Na channels
48Which of the following drugs is a GABA agonist?
- AZonisamide
- BCarbemazepine
- CLamotrigrine
- DEtomidate
49True or false: benzodiazepines decrease frequency of opening of GABA receptors.
- AVerdadeiro
- BFalso
50Which route should you not use for lorazepam or midazolam?
- AIV
- BIM
- CIntranasal
- DIntrarectal
51Which benzodiazepine inhibits T-type calcium channels?
- ADiazepam
- BClonazepam
- CMidazolam
- DLorazepam
52What is not a side effect of barbiturates?
- AHepatotoxicity
- BAutoinduction of CYP450
- CSedation
- DAnorexia
53True or false: barbiturates enhance GABA A by increasing the frequency of opening of the chloride channel.
- AVerdadeiro
- BFalso
54Which of the following drugs works by competing with chloride, hyperpolarizing the neuronal membranes?
- AGabapentin
- BMidazolam
- CPotassium bromide
- DPhenobarbital
55Which of the following can potassium bromide be used for?
- AOnly emergencies
- BOnly add on
- CBoth
- DNeither
56Which is not a mechanism of action of felbamate?
- ABlocking NMDA-mediated neuronal excitation
- BPotentiation of GABA-mediated neuronal inhibition
- CInhibition of voltage sensitive neuronal Cl channels
- DProtects neurons from hypoxic or ischemic damage
57True or false: felbamate is well absorbed from oral administration and has a wide safety margin
- AVerdadeiro
- BFalso
58Which of the following drugs has absorption depending on an L-amino acid carrier, making the process saturable?
- ALevetiracetam
- BGabapentin
- CFelbamate
- DPhenobarbital
59True or false: pregabalin has a long half life
- AVerdadeiro
- BFalso
60Which of the following drugs works by binding to SV2A?
- AZonisamide
- BGabapentin
- CFelbamate
- DLevetiracetam
61Which of the following drugs is partially excreted unchanged and partly glucuronidated?
- AZonisamide
- BGabapentin
- CFelbamate
- DLevetiracetam
62Which of the following drugs weakly inhibits GABA transaminase and has some effect on sodium and T-type calcium channels?
- APhenytoin
- BValproate
- CVigabatrin
- DCarbamazepine
63Which of the following drugs is metabolized by mixed function oxidases and is well absorbed orally?
- APhenytoin
- BValproate
- CVigabatrin
- DCarbamazepine
64Which of the following drugs inhibits GABA transaminase by forming an irreversible covalent bond, resulting in increased GABA?
- APhenytoin
- BValproate
- CVigabatrin
- DCarbamazepine
65Which of the following is a tricyclic antidepressant with hepatic metabolism that is a strong inducer of hepatic enzymes?
- APhenytoin
- BValproate
- CVigabatrin
- DCarbamazepine
66BEHAVIOR MODIFIERS: Which of the following is not an indication of psychotropic drugs in vetmed?
- ASedation and major tranquillizers
- BBehavioral disorders
- CCentral analgesia
- DPeripheral anesthesia
- EEpilepsy
67Which of the following is false regarding MAOIs?
- AMAOIs inhibit the breakdown of serotonin, norepinephrine, and dopamine
- BMAO-A has only central effects
- CMAO-B has only central effects
- DMAO-B’s substrates are norepinephrine and dopamine
- EMAO-A’s substrates are serotonin, norepinephrine, and epinephrine
68Which of the following is not associated with serotonin syndrome?
- AHypertension
- BHyperthermia
- CMetabolic alkalosis
- DRhabdomyolysis
69Which of the following is an example of an MAOI?
- ASelegiline
- BAmitriptyline
- CClomipramine
- DFluoxetine
- EAlprazolam
70Which of the following is not an adverse effect of selegiline?
- AHyperactivity
- BStereotypic behavior
- CPhobias
71Which of the following drugs is incorrectly matched with its indication?
- ASelegiline—dementia in dogs
- BClomipramine—separation anxiety
- CFluoxetine—aggression in male dogs
- DFFP—urine spraying in cats
727. True or false: SNRIs are metabolized via CYP450
- AVerdadeiro
- BFalso
73What isn’t an adverse effect of SNRIs?
- AHypertension
- BTachycardia
- CArrhythmia
- DSalivation
- EConstipation
74Which of the following is true about SNRIs according to slide 11 (e.g. generally)?
- AThey have antihistamine effects
- BThey have anticholinergic effects
- CThey’re alpha-1 antagonists
- DThese are all true!
75Which of the following is not an indication for SNRI use in dogs?
- AExcessive arousal (mild aggression)
- BInappropriate urination
- CCompulsive disorders
- DAnxiety
76Which SNRI has analgesic properties?
- AAmitriptyline
- BImipramine
- CClomipramine
77Which SNRI has equal effects on serotonin and norepinephrine?
- AAmitriptyline
- BImipramine
- CClomipramine
78Which SNRI is used for separation anxiety and canine compulsive disorders?
- AAmitriptyline
- BImipramine
- CClomipramine
79Which is an indication for SSRIs in cats?
- ASeparation anxiety
- BImpulse aggression
- CCompulsive behavior
- DDominance
80Which is not an adverse effect of fluoxetine?
- AGI effects
- BLethargy
- CDepression
- DPolyphagia
81True or false: the metabolites of benzodiazepines are not active.
- AVerdadeiro
- BFalso
82True or false: in a dopaminergic synapse the enzyme beta-dopamine hydroxyls is missing
- AVerdadeiro
- BFalso
83Neuroleptics block which of the following?
- AACH-M receptors
- BAlpha-adenoreceptors
- CHistamine receptors
- DSerotonin receptors
- EAll of the above
84Which of the following is an incorrect example of receptor cross talk?
- AAdrenergic a2-receptor stimulation increases the release of dopamine and serotonin
- BAdrenergic B-receptor stimulation inhibits release of serotonin
- CDopamine down-regulates serotonin auto-receptors
- DAll of the above are true!
85True or false: progestins and estrogen suppress the excitatory effects of glutamate.
- AVerdadeiro
- BFalso
86True or false: it’s totally fine to combine MAOIs and TCAs.
- AVerdadeiro
- BFalso
87SEDATIVES AND TRANQUILLIZERS: Which is not a therapeutic target for these?
- AGABA agonists
- BNMDA antagonists
- CD2 receptor
- DAlpha 1 receptor agonists
88Which is not a mechanism of action of phenothiazines?
- ABlock D2 receptors in the CNS
- BBlock alpha adrenoceptors in the CNS
- CBlock D receptors in the periphery
- DBlock alpha receptors in the periphery
89What is not an effect of phenothiazines?
- ACNS depression
- BPeripheral vasodilation
- CGood muscle relaxation
- DAnalgesia
90True or false: phenothiazines have extensive hepatic metabolism and metabolites are excreted in bile
- AVerdadeiro
- BFalso
91Which of the following is false?
- AYou should use chlorpromazine in horses
- BSome boxers have an exaggerated reaction to acepromazine
- CAcepromazine prevents occurrence of halothane induced malignant hyperthermia in pigs
- DPhenothiazines can be used to treat feline lower urinary tract disease
92Which is false about the mechanism of action of benzodiazepines?
- AThey bind to and activate the benzodiazepine binding site on the GABA-A receptor
- BThey decrease the opening frequency of the Cl channel
- CThey hyperpolarize the post-synaptic membrane
- DAll of the above are true
93Which GABA receptor subunit, when mutated, prevents binding of volatile and injectable agents?
- AAlpha
- BBeta
94Which of the following is not an effect of benzodiazepines?
- ADose dependent muscle relaxation
- BBiphasic cardiovascular response
- CMild respiratory repression
- DDose dependent CNS depression
- EAnalgesia
95True or false: benzodiazepines are reduced or glucuronidated and either excreted via the kidneys (diazepam) or both in the kidney and bile (lorazepam)
- AVerdadeiro
- BFalso
96Which benzodiazepine has active metabolites?
- AMidazolam
- BZolazepam
- CDiazepam
- DLorazepam
97In which patients should you not use benzodiazepines?
- AThose with fear-induced aggression
- BThose with hypersensitivity to benzodiazepines
- CThose with hepatic dysfunction
- DAll of the above
98True or false: flumazenil is a benzodiazepine antagonist that has a high affinity for the BZ-binding sites.
- AVerdadeiro
- BFalso
99Which of the following is false regarding a2 agonists?
- AThey target GPCRs Gi and Go
- BTheir target has 7 transmembrane domains
- CA2B is the most important type of receptor for analgesia and anesthesia
- DThey’re used for sedation, chemical restraint, and analgesia, as well as for emesis
in cats
100Which of the following is not an effect of a2 agonists?
- ADepressive on the CNS, reduces blood flow and O2 consumption
- BMild, dose dependent respiratory depression
- CPoor muscle relaxation
- DAnalgesia
- EBiphasic cardiovascular response
101Which of the following is false regarding a2 agonists?
- AIt can be administered parenterally, orally, or epidurally
- BIt’s synergistic with opioids, local anesthetics, and NMDA antagonists
- CMedetomidine has a strong correlation between the effect and plasma concentration
- DBioavailability of medetomidine is 100% in dogs and cats
102In which animal can a2 agonists cause hypercapnia?
- AHorse
- BCattle
- CSheep
- DCat
103In which animal does xylazine cause activation of pulmonary intravascular macrophages, resulting in acute lung injury?
- AHorse
- BCattle
- CSheep
- DCat
104Which animal has an a2D receptor, making them more susceptible to the effects of sedatives?
- AHorse
- BCattle
- CSheep
- DCat
105In whom can you use a2 agonists?
- APatients with diabetes mellitus
- BPatients with epilepsy
- CPatients with compromised cardiac function
- DAgitated animals
106Which of the following regarding a2 antagonists is true?
- AThey’re competitive antagonists at the a1 receptor
- BThey have varying effects on the a2 receptor
- CThey have varying effects at the a1 receptor
- DAll of the above are false
107Which of the following is a non-selective a-adrenergic antagonist?
- ATolazoline
- BYohimbine
- CAtipamezole
- DRomifidine
108True or false: the answer to the previous question also has histaminergic and cholinergic effects
- AVerdadeiro
- BFalso
109Butyrophenone derivatives work via all of the following except:
- AAntagonism of the D2 receptor
- BAntagonism of the a2 receptor
- CSome antihistaminergic properties
- DAll of the above are true
110Which of the following is not an effect of butyrophenones?
- ACNS depressive
- BCardiovascular depressive
- CReduced muscle tone
- DAnalgesia
111ANESTHESIA & ANALGESIA: Which is not a post-synaptic target for these drugs?
- AAMPA receptors
- BSynaptic vesicle proteins
- CNMDA receptors
- DEAAT
112Which receptor type is incorrectly matched with its number of subunits?
- ANMDA—7
- BAMPA—4
- CKainite—5
- DAll of the above are correct!
113Which ion blocks NMDA receptors?
- ACa
- BNa
- CMg
- DK
114Activation of glutamate receptors requires the binding of which of the following?
- AGlutamate
- BGlycine
- CBoth
- DNeither
115Where do almost all anesthetics potentiate the action of GABA?
- AGABA-A
- BGABA-B
- CGABA-C
- DSomewhere else entirely
116Which ion passes through the channel in the GABA receptors?
- ANa
- BCa
- CCl
- DMg
117Generally how many subunits are present in GABA receptors?
- A3
- B4
- C5
- D6
118True or false: tyrosine hydroxylase (TH) is the rate limiting step in dopamine neurotransmission
- AVerdadeiro
- BFalso
119Which of the following dopamine receptors increase adenylate cyclase activity (thereby increasing cAMP)?
- AD1
- BD2
- CD3
- DD4
120True or false: presynaptic receptors are the clinically relevant ones in the a2 adrenergic synapse (on the slide from the review…)
- AVerdadeiro
- BFalso
121HISTAMINE & SEROTONIN: Which is false regarding autacoids?
- AThey’re local hormones
- BThey’re long-lived
- CThey include histamine, serotonin, nitric oxide
- DThey include angiotensin and eicosanoids
122Which of the following is not mediated by H1?
- AInflammation
- BAllergies
- CGastric acid secretion
- DAnaphylaxis
123Which of the following is an H3 effect?
- ASmooth muscle contraction
- BRelaxing small arterioles
- CGastric acid secretion
- DModulating neurotransmitter release in the CNS
124Where do you not have H4 receptors?
- ADendritic cells
- BMast cells
- CBasophils
- DEosinophils
125Which of the following is false regarding the production of histamine?
- AYou start with histidine
- BHistidine decarboxylase is the enzyme
- CThe group removed to form histamine is CO2
- DAll of the above are true!
126Which of the following is true regarding histamine stores?
- AThe mast cell pool synthesizes histamine more quickly than the non-mast cell pool
- BThe non-mast cell pool occurs in basophils
- CThe mast cell pool continuously synthesizes and releases histamine
- DThe mast cell pool plays a key role in drug reactions
127In order to release histamine from mast cells, the cells must become more permeable to which ion?
- ANa
- BCa
- CCl
- DK
128Which of the following is not a role of histamine?
- AStimulate sensory nerve endings
- BRelax arterioles
- CDecrease capillary permeability
- DAll of the above are roles of histamine!
129Which is not an effect of histamine on the cardiovascular system?
- ADilation of terminal arterioles
- BDecrease in blood pressure briefly
- CDilation of large arteries and veins
- DEdema from increased capillary permeability
130Which of the following is true regarding histamine-mediated vasodilation?
- AH2 has a long duration
- BH1 mediated is slow onset
- CH2 is at small doses
- DH2 induces high levels of tachycardia
131In which group of animals does histamine relax bronchial smooth muscle?
- ARabbits and dogs
- BCalves and pigs
- CCats and sheep
- DHumans and guinea pigs
132Which other smooth muscles are contracted by histamine?
- AIntestinal muscle
- BUterine smooth muscle
- CNeither
- DBoth
133Which of the following is true?
- AH1 is Gi while H2 is Gq
- BH1 is Gq while H2 is Gs
- CH1 is Gs, H2 is Gq
- DH1 is Gs, H2 is Gi
134Which of these other receptors has the same pathway as endothelial H1 receptors?
- AAlpha 2
- BM3
- CD1
- DNm
135True or false: histamine is poorly absorbed from parenteral administration
- AVerdadeiro
- BFalso
136Which is NOT part of the the metabolism of histamine:
- AMethylation and oxidation
- BHistamine N-methyltransferase enzyme acts on histamine to form methyl histamine (further acted upon by MAO)
- CHistaminase enzyme cleaves histamine into inactive metabolites
- DAll of them are part of histamine metabolism
137Which of the following is false regarding histamine agonists?
- AHistamine phosphate is used to test for achlorhydria
- BSo is betazole
- CBetazole is more selective
- DHistamine phosphate is more selective
138Which of the following will give you CNS sedation?
- ACetirizine
- BTrimeprazine
- CLoratadine
- DFexofenadine
139Which of the following lacks antimuscarinic effects?
- AChlorpheniramine
- BClemastine
- CDimenhydrinate
- DDesloratidine
140Which of the following is false regarding the pharmacokinetics of antihistamines?
- AYou can use them IV in emergencies (acute anaphylaxis)
- BYou can use them topically
- CThey don’t bind to plasma proteins
- DThey’re excreted in urine and feces
141Which is not a pharmacologic effect of antihistamines?
- AVasodilation
- BRelaxation of bronchiolar smooth muscle
- CRelaxation of intestinal smooth muscle
- DLocal anesthetic action
- EAnti-inflammatory response
- FInhibits arterial hypertension
- GAnti-motion sickness
142What is not a therapeutic use of antihistamines in bovines?
- ABloat
- BAcetonemia
- CMastitis
- DGut edema
- EMetritis
- FPregnancy toxemia
- GPulmonary emphysema
- HRetained placenta
143Which of the following is not a therapeutic use of antihistamines?
- AMyoglobinuria
- BPeriodic opthalmia
- CGastric stasis
- DLaminitis
144Which antihistamine can cause polyphagia, sedation, increased vocalization, and vomiting in cats?
- ACyproheptadine
- BTrimeprazine
- CChlorpheniramine
- DDiphenhydramine
145True or false: antihistamines can cause hyperexcitability and convulsions at high doses
- AVerdadeiro
- BFalso
146Which is false regarding cromolyn sodium?
- AIt inhibits the release of histamine from mast cells
- BIt closes Cl- channels
- CIt’s used for nasal allergies in horses
- DIt’s used for conjunctivitis
147True or false: serotonin is derived from tryptophan
- AVerdadeiro
- BFalso
148Which of the following serotonin receptors is mismatched with their mechanism?
- A5-HT1—Gi
- B5-HT3—Gs
- C5-HT5—Gi
- D5-HT4--Gs
- E5-HT2—Gq
- F5-HT6—Gs
- G5-HT7—Gs
149Which of the following is false regarding the triphasic response to rapid IV injection of serotonin?
- AThe Bezold-Jarisch reflex involves an initial fall in systemic arterial pressure with accompanying reflex tachycardia
- BThe second phase is a short period of a pressor effect
- CThe third phase is a prolonged fall in systemic BP
- DAll of the above are correct!
150Which of the following is not caused by serotonin?
- AContraction of smooth muscles
- BIncreased GIT motility
- CDecreased pulmonary pressure
- DRelaxation of bronchiolar smooth muscle
151Which of the following is not an SSRI?
- ASertraline
- BFluoxetine
- CParoxetine
- DFluvoxamine
- EBuspirone
152Which of the following serotonin agonists would you use to control postpartum hemorrhage and for uterine involution? (Hint: it’s an agonist of the 5-HT2 receptor!)
- ACisapride
- BErgometrine
- CMetoclopramide
- DCyproheptadine
153Which drug is used for constipation and megacolon in cats? (But let’s be honest here, all I care about is its use for stasis in rabbits.)
- ACisapride
- BErgometrine
- CMetoclopramide
- DCyproheptadine
154Which drug is an agonist of the 5-HT4 receptor and a D2 antagonist that, while being useful for gastric stasis and anti-emesis, can also change your mood/behavior?
- ACisapride
- BErgometrine
- CMetoclopramide
- DCyproheptadine
155Which antagonist of the 5-HT1 receptor (and first gen antihistamine) is used for head shaking in horses and feline asthma?
- AKetaserin
- BCyproheptadine
- CMethysergide
- DOndansetron
156Which of the following is an antagonist of the 5-HT2 receptor and alpha adrenergic receptor, antihistamine, and is used for glaucoma?
- AKetaserin
- BCyproheptadine
- CMethysergide
- DOndansetron
157Which drug (that sounds like a transformer) is used as an antiemetic during chemotherapy?
- AKetaserin
- BCyproheptadine
- CMethysergide
- DOndansetron
158Which 5-HT2 antagonist is used for carcinoid syndrome (cancerous tissues producing too much serotonin)?
- AKetaserin
- BCyproheptadine
- CMethysergide
- DOndansetron
Informações
- Descrição
- Final Pharmacology I Quiz from Veterinary Pharmacology I taught by Dr. Werners, and Lady Dr. Kumar
- Autor
- MRaythe
- Idioma
- English
- Visualizações
- 335
- Etiquetas
- Avaliação
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