Flashcards
Prostaglandin Synthase & Multi-Enzyme Complexes
Flashcards do conjunto (21)
- 1Prostoglandin SynthaseConverts Arachidonate to Prostoglandin H2
- 2Role of ProstoglandinCauses inflammation and modulates gastric acid levels
- 3No of enzyme centres in Prostoglandin synthase2
- 4CyclooxygenaseArachidonic Acid + O2 --> Prostoglandin G2
- 5PeroxidaseProstoglandin G2 --> H20 + Prostoglandin H2
- 6Monotopic proteinAttached to the membrane from one side
- 7Attachment of Prostoglandin synthaseHydrophobic alpha helices
- 8Integral/PeripheralPeripheral, but binds strongly enough to be classed as integral
- 9Can be detached by...Detergent
- 10Location of PSInner membrane- as requires substrate of membrane lipid hydrolysis
- 11Substrate of P.SHydrophobic
- 12Travel of SubstrateMoves through hydrophobic channel in membrane to active site devoid of water
- 13Binding of aspirin/ibruprofinSerine 540
- 14Enzyme complexes require...A high degree of subunit communication
- 15Why have M.E.C's?Allow specialized function
- 16ChargeCan prevent M.E.C's forming in the wrong conditions
- 17Reason for Complex- ProductProduct of one enzyme is so reactive/expensive it's better to pass it directly along a complex
- 18Reason for Complex- SpeedEnzymes are brought closer together and so reactants move between active sites faster
- 19Reason for Complex- Substrate cyclingAllows cycle to happen so heat can be released
- 20Positive Collisional InteractionTwo molecules collide and have enough energy to react
- 21Negative Collisional InteractionTwo molecules collide/don't react due to shape/charge/size issues
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- Structural Basis for Biological Function (Membrane Proteins) FlashCards sobre Prostaglandin Synthase & Multi-Enzyme Complexes, criado por gina_evans0312 em 14-12-2013.
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