Flashcards
Cancer chemo drugs
Cards in this deck (33)
- 15-FU ((class))Anti-metabolite
- 2Methotrexate ((class))Antimetabolite
- 3Mercaptopurine ((class))Anti-metabolite
- 4Bleomycin ((class))Anti-biotic type agent
- 5Doxorubicin ((class))Anti-biotic type agent
- 6Chlorambucil ((class))Alkylating agent
- 7Carboplatin ((class))Alkylating agent
- 8Flutamide ((class))Hormone Inhibitor/Antagonist
- 9Cyproterone (Class)Hormone Inhibitor/Antagonist
- 10Tamoxifen (Class)Hormone Inhibitor/Antagonist
- 11Letrazole (Class)Hormone Inhibitor/Antagonist
- 123 sub classes of hormone inhibitors/antagonistsAnti-androgenic
Anti-estrogen
Aromatase inhibitors - 133 sub-classes of antimetabolitesFolic acid analogues
Pyrimidine analogues
Purine analogues - 14Alkylating agents (MOA)Bind to DNA
Disable cellular DIVISION mechanism - 15Anti-biotic type agents (MOA)Bind to DNA
Prevent RNA & Protein synthesis - 16Antimetabolites (MOA)Incorporate into DNA structure during replication - misreading of code & DNA breakage
- 17Methotrexate (MOA)Inhibits dihydrofolate reductase -
disrupts synthesis of nucleic acids - 185-FU (MOA)Blocks synthesis of pyrimidne nucleotides
- 19Mercaptopurine (MOA)Blocks synthesis of purine analogues
- 20Anti-androgenics (MOA)Inhibit prostate androgen uptake
- 21Anti-estrogen drugs (MOA)Inhibit IGF-1 & TGF
(Breast Cancer) - 22Aromatase inhibitors (MOA)Blocks estrogen synthesis
(Advanced breast cancer) - 23Alkylating agents (Adverse effects)BM suppression
Leukopenia
Mouth ULcers
Bleeding * GID
Liver Damage - 24Anti-biotic type agents (Adverse effects)BM suppression
Alopecia
GID
Hyperpigmentation - 25Methotrexate (Adverse effects)Liver damage
GID
Pulmonary toxicity - 26Anti-metabolites (General toxic Adverse effects)BM suppression
GIT damage (Ulceration, inflammation) - 27Hormone inhibitors/anatagonists (Common AE's)GID
Impaired fertility
menstrual irregularities - 28Anti-androgenics (Adverse effects)Toxic hepatitis
gynecomastia
Decreased libido
impotence - 29Anti-estrogen drugs (Adverse effects)Hot flushes
dizziness
thromboembolism - 30Thalidomide (MOA)Direct effect on myeloma cells.
Antiangiogenic activity
Immunomodulator - 31Thalidomide (AEs)Neutropenia
neuropathy
orthostatic hypotension
dizziness
seizures
sedation - 32Thalidomide & cytotoxic AB (interaction effect)neuropathies
- 33Thalidomide & alcohol/narcotics/benzos (interaction effects)CNS depression
(can lead to death)
Information
- Description
- Flashcards on Cancer chemo drugs, created by Mark George on 20/07/2014.
- Created by
- Mark George
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