Flashcards
receptors
Cards in this deck (19)
- 1what is signal transductiona process by which a signal/stimulus is converted into a response
- 2what are signalling molecules?(eg hormones) bind to receptor proteins in the cell membrane causing a response.
- 3what are endocrine signals?hormones that travel through the blood to all parts of the body
- 4what ae paracrine signals?signals that target only receptors in the vicinity of the emitting cell, neurotransmitters are an example of this
- 5what areaurocrine signals?signals that only effect cells of the same cell type as the emitting cell e.g. immune cells
- 6what are the two classes of hormone receptors?1. transmembrane receptors
2. intracellular/nuclear receptors - 7what are the 6 hormone initiated signal transduction steps?1. biosynthesis
2. secretion and storage
3transportation to target cell
4.recognition by hormone receptor
5.relay + amplification of signal
6. removal of protein - 8what do transmembrane receptors allow for?communication across the membrane
- 9what is the definition of a receptor?“Receptors” are macromolecular proteins that participate in intracellular communication via chemical signals, such as hormones
- 10name two types of proteins receptors are often made ofglycoproteins
lipoproteins - 11how many binding sites does a receptor have?one or more
- 12how does an endogenous ligand (e.g. hormone) activate a receptor?by inducing a conformational change
- 13how many signals can be generated from a ligand binding to receptor?could be one or more
- 14name the four main features of receptors1. made of proteins
2. have binding sites (1 or more)
3. activated by endogenous ligands
4. generate signals (1 or more) - 15what 2 things mustt receptors have properties ofrecognition
transduction - 16what determine the total magnitude of the transmembrane signal production?the fraction of total membrane receptors occupied by the ligand
- 17why are receptors saturable?due to finite numbers of receptors
- 18antagonists and agonists compet with what for binding sites?endogenous transitters
- 19how do Allosteric agonists or antagonists enhance or block signals?by binding to allosteric sites that influence signal transmission
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- Degree drugs and disease (material upto 25th feb- class test) Flashcards on receptors, created by danielle cox on 22/02/2015.
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- danielle cox · Feb 2015
- Updated
- Feb 19, 2016
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