Flashcards
Diabetes Mellitus
Cards in this deck (6)
- 1Diabetes MellitusDisturbance of glucose homeostasis
- 2Action of insulin on: - Liver - Muscle - Fat- inhibits gluconeogenesis
& increase glycogen production
- increase protein synthesis
- increase fat storage - 3Insulin deficiency or resistance results in...- Gluconeogenesis
- Protein catabolism
- Lipolysis - 43 factors causing HYPERGLYCAEMIA in DM1. Decreased tissue utilisation of glucose, amino acids and fatty acids
2. Increased hepatic gluconeogenesis
3. Accumulation of dietary glucose in circulation - 5Type I DM1. Commonly seen in DOGS
2. Insulin- dependent
3. Immune-mediated destruction of pancreatic beta cells that results in progressive and complete loss of insulin secretion
4. Absolute requirement for exogenous insulin - 6Type II DM1. Commonly seen in CATS
2. Non-insulin dependent
3. Impaired insulin secretion by dysfunctional beta cells and peripheral insulin resistance (i.e. impairs post-prandial glucose uptake)
4. Loss of beta cell function is usually progressive and may result in complete loss of insulin secretion