THIRD LINE IMMUNE RESPONSE

THIRD LINE IMMUNE RESPONSE

1. ADAPTIVE IMMUNE RESPONSE

   • CHARACTERISTICS
     • SPECIFIC
     • ACTIVATE AFTER INFECTION
     • THE MAGNITUDE FOR SECOND INFECTION IS HIGHER COMPARED FOR THE FIRST TIME
     • MEMORY OF PREVIOUS INFECTION IS STORED

2. DEVELOPMENT OF b AND t CELLS

   • LYMPHOCYTE DEVELOPMENT
     • T CELLS (THYMUS)
     • B CELLS (BONE MARROW
   • FUNCTION
     • BIND TO RECEPTOR OF OTHER CELL
     • BIND TO THE ANTIGEN
     • TRANSMIT AND RECEIVE MESSAGE

3. ANTIGENT

   • SUBSTANCE THAT PROVOKE THE IMMUNE RESPONSE
     • EPOTOPE IS ANTIGENIC SPECIFICITY

4. ANTIGENICITY

   • FACTOR
     • -SIZE , COMPLEXITY, FOREIGN

5. MAJOR HISTOCOMPATIBILITY

   • CLASS 1
     • EXPRESSE ON ALL NUCLEATED CELL
   • CLASS II
     • ON ANTIGENT PRESENTING MICROPHAGES
   • CLASS III
     • FOUND IN PROTEIN

6. T CELLS RESPONS

   • HELPER T CELLS
     • Stimulate or activate other cell release cytokines
   • memory t cells
     • store the memory after 1 infection
   • regulatory t cells
     • -regulate other -prevent inflammation
   • CYTOTOXIC T CELLS
     • Have granzymes and perforinse to kill the bacteria -attack cancer cell and foreigner

7. B cell

   • -can activate without helper T cell (independant cases) -B cell can activate by helper T cell (MAJOR)
   • diffrentiate
     • memory B cell
     • regulatory B cell
       • -act same as regulatory T cell
     • plasma cell
       • release antibodies
         • ANTITOXIN ACTION
         • NEUTRALISATION
         • AGGLUTINATION
         • OPSONISATION

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