Complement System Mind Map

Complement System Mind Map

1. CLASSICAL

   • Complement proteins binds to Fc part of antibody -Activated C1 triggers C4 and C2 = C3 CONVERTASE -Activation of C3 is an important AMPLIFICATION step 
   • Initiated by: Antigen:Antibody complex (antibody required)
   • ALL

2. MB LECTIN

   • Binds to bacterial glycoproteins -Creates C1-like activator  (Activates C4, C2 = C3 Convertase)
   • Initiated by: Mannose-binding Lectin (innate)
   • Converge
     • C3b = OPSONIZATION (C3b binds to CR1 receptor) coating of virus blocks receptors and makes uptake easier
       • enhances Immune complex clearance: from classical 
       • "MAC" Membrane Attack Complex C5b triggers the MAC: Forms a pore to cause lysis of target cell
         • C5b678 = interior of MAC complex -C9 = exterior of MAC complex 
     • C3a & C5a ANAPHYLATOXINS C5a = most potent & dominant INFLAMMATORY toxin -leads to: vascular permeability of blood vessels
       • Blood vessels open up: -Diapedisis -extraversion of complement protein 

3. ALTERNATIVE

   • -C3 sponateously turns over C3a and C3b (ALWAYS IN SERUM) NATURAL turn over of C3a and C3b-Creates alternative C3 and C5 Convertase leading to MAC formation
   • Initiated by: does not involve antibody binding (innate) -activated by pathogenic peptide (PAMPs) -Alt C3 convertase and Alt C5 convertase (C5b-MAC AND C5a-Inflammation)
   • at C3 CONVERTASE (C3b-Opsonization AND C3a Inflammatory)

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