IMMUNISATION OF CARIES

IMMUNISATION OF CARIES

1. VACCINATION AGAINST S.MUTANS

   • BOWEN 1969: Injected live strain of S.mutans IV to monkeys
     • they were then fed a cariogenic diet
       • After 1yr: control - 38 cavities+13 early lesions
         • Vaccinated - 6 cavities+4 early lesions
           • 2nd EXPERIMENT: broken cells of S.mutans injected into oral mucosa
             • Control- 64 cavities
               • Vaccinated - 0 cavities

2. RAT STUDIES

   • S.mutans administered via subcutaneous inoculation
     • this induced salivary sIgA
       • they were then inoculated with the bacteria, reduced level bacteria recovered
         • Hence reduced carious lesions

3. ANTIGEN OF S.MUTANS

   • Protein antigen I/II
     • Glucosyltranferase - accumulation
       • Glucen binding proteins - phase III
         • Lehner 1980 - monkey experiments

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