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Antibiotics Lecture
Fichas del conjunto (27)
- 1List the beta lactam agentsPenicillin
Beta-lactam/Beta-lactamase inhibitors
Cephalosporins
Carbapanems
Monobactam - 2Baseline chemical structure of beta lactam4 member ring surrounded by 5 member ring
-Penicillin
-Beta-lactamase inhibitors
-Carbapanems - 3Cephalosporins structure4 member ring + 6 member ring
- 4Monobactam structureJust 4 member ring
- 5How do PCN work?Disrupting cell wall synthesis
- 6PCN resistance-production of beta-lactamase
-alteration in PBP
-decreased permeability - 7What is the primary method of excretion of PCN?Via Renal
- 8What PCNs are not excreted via renal? How are they excreted?-Piperacillin,
-Oxacillin,
-Nafcilin
Via biliary excretion - 9Plain penicillinStreptococci (A, B, C, G) & Syphilis
- 10Oxacillin/NafcillinStreptococci (A,B,C,G) & staphylococci
(Doesn't include MRSA) - 11Ampicillin-Has an additional side chain
-Reasonable gram negative
-E.coli, hemophalus influenza, Listeria, enterococcus
-Has some resistance built up towards it - 12Piperacillin-Pseudomonas, other gram negative, enterococcus
- 13Drug of choice for enterococcusAmpicillin
- 14Adverse effects of PCNAllergic Reactions
Bone Marrow Effects
Interstitial Nephritis
Seizures - 15Allergic Reactions of PCNAnaphylaxis (almost immediately)
Immediate hypersensitivity (hours to day)
Delayed hypersensitivity (7-10 days after) - 16List the BL/BLase Inhibitor CombinationsAmoxicillin/Clavulanic Acid (Augmentin)
Ampicillin/Sulbactam (Unasyn)
Ticarcillin/Clavulanic Acid (Timentin)
Piperacillin/Tazobactam (Zosyn) - 17Augmentinamoxicillin & clavulanic acid
- 18UnasynAmpicillin & Sulbactam
- 19TimentinTicarcillin & Clavulanic Acid
- 20ZosynPiperacillin & Tazobactam
- 21BL/BLAI drugs work best against what type of bacteria?anaerobes and gram negative bacteria
- 22How does BL/BLAI work?Inhibitor binds irreversibly to Beta-lactamase
- 23How do cephalosporins work?-Disrupt cell wall synthesis
-Resistance mechanisms similar to penicillin - 24CEPHS resistance-Similar to penicillin
-production of beta-lactamase
-alteration in PBP
-decreased permeability - 25CEPHS excretionRenal mainly
- 26What CEPH is not excreted by the main way, and by what method is it?Ceftriaxone
Biliary excretion - 27CEPH generation pattern1st - more active against gram positive, very small
Información
- Descripción
- Professional (Exam 2) POD Fichas sobre Antibiotics Lecture, creado por Amaal Salhieh el 12/04/2016.
- Creado por
- Amaal Salhieh
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