Fatty Acid Metabolism

Fatty Acid Metabolism

1. Fatty acid degradation

   • Occurs via oxidation
   • 1. Oxidation at the aB bond to a 2x bond
     • 2. Hydration of the aB double bond, with -OH added to the Beta Carbon
       • 3. Oxidation of the B hydroxyl group to a ketone/carbonyl
         • 4. Cleavage at the alpha carbon between two carbonyls via thiolysis.

2. Fatty acid synthesis

   • 1. Condensation of the malonyl CoA and acetyl CoA
     • 2. Reduction of the Beta ketone closest to the alkyl chain