Flashcards
Adenylate Cyclase & Why cAMP
Cards in this deck (12)
- 1A monomer/dimer/heterodimer?Dimer
- 2How many membrane spanning loops in each monomer?6
- 3Where is the catalytic site?Inside the cell
- 4What activates adenylate cyclase?The alpha subunit of Gs protein
- 5What effect does the binding of the alpha subunit have?The two halves of the catalytic site combine and activate
- 6What does adenylate cyclase produce?3,5-cAMP
- 7Why cAMP? A variety of hormones...can activate the same pathway in different tissues
- 8Why cAMP? A hormone can activate...Different pathways in different tissues
- 9Why cAMP? The same hormone doesn't have to...Activate the same pathway, even if the pathway's only regulated by one mechanism
- 10What is cAMP (as part of the cascade)?A secondary messager
- 11What effect does the cholera toxin have on Adenylate Cyclase?Binds ADP-Ribose to the alpha-s subunit, which prevents it rebinding to the g-protein
- 12What effect does the pertussis toxin have on g-protein alpha subunit?Binds ADP-Ribose to the alpha-i subunit, which prevents it separating from the g-protein
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- Year 2 Flashcards on Adenylate Cyclase & Why cAMP, created by gina_evans0312 on 29/10/2013.
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