Flowchart
Virus Infection and Replication
Flowchart content
+(ss)RNA tricks host cells into thinking it is mRNA
Binds to ribosomes
translation and viral protein synthesis
-(ss)RNA cannot bind to host ribosomes
Using packaged polymerase, transcribes to +(ss)RNA
How positive sense and negative sense viral RNA works
RNA dependent RNA polymerase
General Phases of Animal Virus Multiplication Cycle
Adsorption (attachment)
Penetration (entry)
Uncoating
Synthesis
Assembly
Release
binding of virus to specific molecule on host cell -- may require viral spirke
genome enters host cell (different for envelop vs. nake virus)
the viral nucleic acid is released from the capsid
viral production of proteins (structural and enzymatic) and replication of genome
new viral particles are constructed & synthesis of nucleocapsid
viruses are released by budding (exocytosis) or cell lysis
Synthesis of DNA Virus
dsDNA
dsDNA
copy
DNA-dependent DNA polymerase
copies both + & - DNA strands
viral genome
mRNA
(+ssRNA)
DNA dependent RNA polymerase
transcription
viral proteins
(structural - capsid)
(functional - enzymes)
Translation
Assembly
viral protein
ssDNA
produces complementary DNA strand and forms dsDNA
Synthesis of +(ss)RNA Virus
+(ss)RNA
Virus
viral proteins
& polypeptides
translation acts as mRNA
transcription by RNA dependent RNA polymerase
-(ss)RNA
copies of +(ss)RNA (genome)
transcription
viral protein
assembly
Synthesis of -(ss)RNA Virus
viral protein
viral proteins
& polypeptides
-(ss)RNA Virus
+(ss)RNA
translation
transcription by RNA depdendent RNA Polymerase
copies
-(ss)RNA
transcription
assembly
Synthesis of (ds)RNA Virus
+(ss)RNA
viral proteins
translation
-(ss)RNA
transcription by viral RNA polymerase
complementary strands
viral protein
assembly
(ds)RNA virus
unwinding
Information
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- Microbiology Flowchart on Virus Infection and Replication, created by Rachel Rivera on 16/09/2018.
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- Rachel Rivera
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