Thrombosis

melian.yates
Mind Map by melian.yates, updated more than 1 year ago
melian.yates
Created by melian.yates over 6 years ago
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Doctorate Pathology Mind Map on Thrombosis, created by melian.yates on 10/20/2013.
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Thrombosis
1 Casual Factors
1.1 Virchows Triad
1.1.1 1) Endothelial Injury
1.1.1.1 Viruses
1.1.1.1.1 Bacteria
1.1.1.1.1.1 Fungi
1.1.1.1.1.1.1 Toxins
1.1.1.1.1.1.1.1 Immune mediated vasculitis
1.1.1.1.1.1.1.1.1 Disseminated Intravascular Coagulation (DIC)
1.1.1.1.1.1.1.1.1.1 Local extension of Infection
1.1.1.1.1.1.1.1.1.1.1 Intravenous Injections or indwelling catheters
1.1.1.1.1.1.1.1.2 Purpura Haemorrhagica (Horses with Strep. equi infection)
1.1.1.1.1.1.1.2 Strongylus vulgaris larvae
1.1.1.1.1.1.2 Aspergillus
1.1.1.1.1.2 Salmonella typhimurium, erysipelothrix
1.1.1.1.2 Canine adenovirus, Equine herpesvirus
1.1.2 2) Abnormal Blood Flow
1.1.2.1 Heart disease or Hypovolemia
1.1.2.1.1 Systemic reduction in blood flow
1.1.2.1.1.1 Ex. Dilated cardiomyopathy
1.1.2.2 Local reduced flow/stasis
1.1.2.2.1 Gastric dilatation & volvulus
1.1.2.2.1.1 Stomach swells and twists
1.1.2.2.1.1.1 Restricts blood flow
1.1.2.2.1.1.1.1 Hypoxia + Stasis => Platelet deposition
1.1.2.2.2 Turbulence
1.1.2.2.2.1 Valvular disease
1.1.2.2.2.2 Aneurysm
1.1.3 3) Hypercoagulability
1.1.3.1 Enhanced platelet activity
1.1.3.1.1 E..g. Diabetes mellitus, Nephrotic syndrome, Malignant neoplasia
1.1.3.2 Increased clotting factor activation
1.1.3.2.1 Ex. DIC
1.1.3.3 Metabolic abnormalities
1.1.3.3.1 E.g. Hyperadrenocorticism
1.1.3.4 Glomerulopathies
1.1.3.4.1 Loss of Anti-thrombin III in urine
2 Thrombi
2.1 Composition
2.1.1 Mainly fibrin + Platelets
2.1.1.1 Pale color:
2.1.2 Mainly fibrin + RBCs
2.1.2.1 Red color:
2.1.3 Layers of RBC + WBC + fibrin
2.1.3.1 Laminated:
2.2 Location
2.2.1 Mural/Parietal
2.2.1.1 Occluding
2.2.1.1.1 Consecutive
2.2.1.1.1.1 Blood backed up behind clot
2.2.1.1.2 As thrombi progress => May block the lumen
2.2.1.2 Attached to the vessel wall & do not occlude the lumen
2.3 Nature
2.3.1 "Bland"
2.3.1.1 Blood constituents only
2.3.2 Infective
2.3.2.1 + Bacteria
2.3.3 Parasitic
2.3.3.1 + Larvae
2.3.4 Neoplastic
2.3.4.1 + Tumor cells
3 Consequences
3.1 Importance of initial thrombus depends on:
3.1.1 1) Location of formation
3.1.1.1 Arterial, Venous, Cardiac (Ischaemia & Hypoxic damage
3.1.2 2) Nature
3.1.2.1 Bland
3.1.2.1.1 Infective
3.1.2.1.1.1 Neoplastic
3.1.2.1.1.1.1 Metastasis
3.1.2.1.1.2 Bacteria
3.1.2.1.1.2.1 Abscess
3.1.3 3) Rate of Formation
3.1.3.1 Rapid development of Thrombus leaves no time for compensation by collateral circulation
3.1.3.1.1 Ex. Pulmonary Thrombi
4 Fate
4.1 Dissolution
4.1.1 Removed by fibrinolysis
4.1.2 Small or recently formed
4.2 Propagation &/or Embolisation
4.2.1 Spread around body as bits break off
4.3 Organization & Recanalisation
4.3.1 Scar tissue & Get lumen of vessel back again
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