Mind Map by melian.yates, updated more than 1 year ago
Created by melian.yates over 6 years ago


Doctorate Pathology Mind Map on Thrombosis, created by melian.yates on 10/20/2013.

Resource summary

1 Casual Factors
1.1 Virchows Triad
1.1.1 1) Endothelial Injury Viruses Bacteria Fungi Toxins Immune mediated vasculitis Disseminated Intravascular Coagulation (DIC) Local extension of Infection Intravenous Injections or indwelling catheters Purpura Haemorrhagica (Horses with Strep. equi infection) Strongylus vulgaris larvae Aspergillus Salmonella typhimurium, erysipelothrix Canine adenovirus, Equine herpesvirus
1.1.2 2) Abnormal Blood Flow Heart disease or Hypovolemia Systemic reduction in blood flow Ex. Dilated cardiomyopathy Local reduced flow/stasis Gastric dilatation & volvulus Stomach swells and twists Restricts blood flow Hypoxia + Stasis => Platelet deposition Turbulence Valvular disease Aneurysm
1.1.3 3) Hypercoagulability Enhanced platelet activity E..g. Diabetes mellitus, Nephrotic syndrome, Malignant neoplasia Increased clotting factor activation Ex. DIC Metabolic abnormalities E.g. Hyperadrenocorticism Glomerulopathies Loss of Anti-thrombin III in urine
2 Thrombi
2.1 Composition
2.1.1 Mainly fibrin + Platelets Pale color:
2.1.2 Mainly fibrin + RBCs Red color:
2.1.3 Layers of RBC + WBC + fibrin Laminated:
2.2 Location
2.2.1 Mural/Parietal Occluding Consecutive Blood backed up behind clot As thrombi progress => May block the lumen Attached to the vessel wall & do not occlude the lumen
2.3 Nature
2.3.1 "Bland" Blood constituents only
2.3.2 Infective + Bacteria
2.3.3 Parasitic + Larvae
2.3.4 Neoplastic + Tumor cells
3 Consequences
3.1 Importance of initial thrombus depends on:
3.1.1 1) Location of formation Arterial, Venous, Cardiac (Ischaemia & Hypoxic damage
3.1.2 2) Nature Bland Infective Neoplastic Metastasis Bacteria Abscess
3.1.3 3) Rate of Formation Rapid development of Thrombus leaves no time for compensation by collateral circulation Ex. Pulmonary Thrombi
4 Fate
4.1 Dissolution
4.1.1 Removed by fibrinolysis
4.1.2 Small or recently formed
4.2 Propagation &/or Embolisation
4.2.1 Spread around body as bits break off
4.3 Organization & Recanalisation
4.3.1 Scar tissue & Get lumen of vessel back again
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