766834
Description
Mind Map by smarshall405, updated more than 1 year ago
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Created by smarshall405
about 11 years ago
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Parasitology
- Malaria pathology (sequestration and rosetting) JB
- sporozoites released, head to
liver, merozoites, sequestration of
PRBC
- Rosetting linked to death in children. Deficiencies in
blood group O and complement recprtor 1 confer
resistance
- PfEMP-1 (part of var gene repertoir) binds to
complement receptor 1 (and others) on IE = rosetting
- Other parasite proteins associated with
knobs
- There are differemt pathogologies associated with dif
receptors (e.g. CSA binding = placental, CD36 binding = mild
malaria, PfEMP-1 and CR1 rosetting = cerebral malaria
- Study covered in lecture:creating a knobless protein. Gene knockdown of
KHARP (knob-associated histidine rich protein), changed antigenic
properties and therefore was less stickiness to CD36. Therefore know that
KHARP causes binding to CD36
- There are differemt pathogologies associated with dif
receptors (e.g. CSA binding = placental, CD36 binding = mild
malaria, PfEMP-1 and CR1 rosetting = cerebral malaria
- Other parasite proteins associated with
knobs
- Rosettes btween normal and infected.
Receptors: PfEMP1 (CR1/CD35), Repetitive
interdispersed family (RIF)
- Sequestration in cerebral malaria causes hemozoin pigment
- Pregnancy: Rosetting doesnt happen, placental parasites have
specific antigens coded by VAR2CSA genes, bind to CSA in the placenta
- sporozoites released, head to
liver, merozoites, sequestration of
PRBC
- Helminths JB
- 1. Platyhelminthes:
Monogeneans,
trematodes, cestodes.
- Trematodes (flukes)
- Shistosoma aka bloodflukes
- S. mansoni: hepatosplenic schistosomiasis
- Egg granuloma in liver, enlarges spleen,
T-helper 2 immune reaction
- Egg granuloma in liver, enlarges spleen,
T-helper 2 immune reaction
- S. mansoni: hepatosplenic schistosomiasis
- Syncitial tegument
- Liver flukes: Clonorchis sinensis, Fasciola
hepatica (not normally human host)
- Shistosoma aka bloodflukes
- Cestodes
- Echinacoccus: Hydatic disease
- swollen stomach: huge immune reaction cos
worm hasn't evolved with humans
- swollen stomach: huge immune reaction cos
worm hasn't evolved with humans
- Echinacoccus: Hydatic disease
- Monogenea
- posterior adhesive organs
- syncytial tegument
- simple one host lifecycle
- Gyrodactylus salaris: salmon ectoparasite
- Rotenone
- Rotenone
- posterior adhesive organs
- Trematodes (flukes)
- Phyla: nematode, aka roundworm
- Ascaris lumbricoides aka human roundworm
- largest, most common human
infective worm.
- Swallow eggs in infected food, travel
from gut to lungs, cough up and swallow
and they lay eggs in gut
- largest, most common human
infective worm.
- Hookworm such as Anclyostoma duodenale
- Whipworm = Trichuris
trichiura
- causes trichuriasis when infects a
human large intestine
- causes trichuriasis when infects a
human large intestine
- Wuchereria bancrofti: lymphatic filariasis
- Aedes, Culex, and Anopheles
- Aedes, Culex, and Anopheles
- Pinworms
- Ascaris lumbricoides aka human roundworm
- 1. Platyhelminthes:
Monogeneans,
trematodes, cestodes.
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