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MO13 Large Molecule Drugs – Antibodies

Mer Scott 14 questions Updated 12 Apr 2018

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Questions in this quiz (14)

  1. 1Which of these is not an advantage of antibodies as medicines?
    1. AThey are very selective and bind tightly to targets
    2. BThey are versatile and effective
    3. CThey have good pharmacokinetics
    4. DThey can be stored as sterile liquids or powders
  2. 2Most antibody medicines are for treating cancer.
    1. ATrue
    2. BFalse
  3. 3Natural [blank_start]polyclonal[blank_end] antibodies have diversity through VDJ (variable, diversity, joining regions) [blank_start]recombination[blank_end] in bone marrow, and from [blank_start]somatic[blank_end] hypermutation during affinity maturation.
    A single antibody is made by a plasma cell aka a [blank_start]B cell[blank_end]
    Many plasma cells make [blank_start]different[blank_end] antibodies, which is a polyclonal response.
    1. Apolyclonal
    2. Bmonoclonal
    3. Crecombination
    4. Dsomatic
    5. Egametic
    6. FB cell.
    7. GT cell.
    8. Hdifferent
    9. Iidentical
  4. 4Antibodies used in therapy are primarily what class?
    1. AIgG
    2. BIgE
    3. CIgD
    4. DIgM
  5. 5Order the steps for production of commercial heterologous polyclonal antibodies:
    [blank_start]1[blank_end]. Inject antigen into animal
    [blank_start]4[blank_end]. Obtain anitserum from animal containing polyclonal antibodies
    [blank_start]3[blank_end]. Plasma B cells make polyclonal antibodies
    [blank_start]2[blank_end]. Antigen activates the B cells
    1. A1
    2. B2
    3. C3
    4. D4
    5. E4
    6. F3
    7. G2
    8. H1
    9. I3
    10. J1
    11. K2
    12. L4
    13. M2
    14. N3
    15. O4
    16. P1
  6. 6Choose the incorrect statement:
    1. AHomologous polyclonal antibodies are made from select donors
    2. BHomologous polyclonal antibodies are used for treating things like tetanus and hepatitis B
    3. CHomologous polyclonal antibodies in NZ are made from blood given by paid New Zealand blood donors
  7. 7Choose the correct statement about heterologous polyclonal antibodies.
    1. AThey are made from man.
    2. BThere is no risk of anaphylaxis.
    3. CThey can only be given as a single dose from any given species.
    4. DThey are not commercially produced.
  8. 8Choose the incorrect statement about homologous polyclonal antibodies.
    1. AThey are made from animals.
    2. BThere is no risk of anaphylaxis.
    3. CThey are used only in specific situations.
    4. DThey are natural antibodies as a result of infection.
  9. 9Monoclonal antibodies are [blank_start]synthetic[blank_end] antibodies produced by [blank_start]recombinant[blank_end] technology. They are defined, IgG, and have [blank_start]no batch variability.[blank_end]
    1. Asynthetic
    2. Brecombinant
    3. Cno batch variability.
    4. Dbatch variability.
  10. 10Monoclonal antibodies are made by injecting an [blank_start]antigen[blank_end] into an animal, and then isolating the immune cells which make the [blank_start]antibody[blank_end]. You then [blank_start]combine[blank_end] this plasma [blank_start]B cell[blank_end] with an immortal [blank_start]tumour cell[blank_end] to make a hybridoma, an immortal cell which forever produces identical, monoclonal antibodies through [blank_start]clonal expansion[blank_end].
    1. Aantigen
    2. Bantibody
    3. Ccombine
    4. DB cell
    5. Etumour cell
    6. Fclonal expansion

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Description
PHCY211 (Molecules) Quiz on MO13 Large Molecule Drugs – Antibodies, created by Mer Scott on 11/04/2018.
Author
Mer Scott
Language
English
Views
5
History
Created on 11 Apr 2018 · updated on 12 Apr 2018
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