GoConqr has a new look! Let us know what you think.

Sign up free

Quiz

MO17 Stability of Large Molecules

Mer Scott 5 questions Updated 13 Apr 2018

Take the quiz

This quiz has question types that open in the usual player.

Questions in this quiz (5)

  1. 1Select all the degradation issues that are non-covalent.
    1. ADenaturation
    2. BAggregation
    3. CAdsorption
    4. DPrecipitation
    5. EDeamidation
    6. FOxidation
    7. GGlycosylation
  2. 2Choose the incorrect statement about aggregation, the formation of macromolecular complexes.
    1. AIt is noncovalent.
    2. BIt is irreversible.
    3. CIt happens via hydrophobic association.
    4. DIt is immunogenic.
    5. EIt does not affecting binding or activity.
    6. FIt could happen because of different interfaces in production, mechanical stress, interaction with metal surfaces or in the presence of other molecules
  3. 3Choose the incorrect statement about oxidation.
    1. AIt is covalent degradation.
    2. BIt occurs on multiple amino acid side chains due to oxygen, light, or peroxide
    3. CIt impacts stability, activity and immunogenicity
    4. DThe most susceptible amino acids are methionine, cysteine, tyrosine, tryptophan, and histidine
  4. 4Deamidation is a [blank_start]covalent[blank_end] degradation which happens to [blank_start]asparagine[blank_end] (Asn) and [blank_start]g;utamine[blank_end] (Gln), removing the amino group. This results in [blank_start]aspartic acid[blank_end] (Asp) and [blank_start]glutamic acid[blank_end] (Glu) respectively, and [blank_start]decreases[blank_end] the activity of the proteins.
    1. Acovalent
    2. Bnon-covalent
    3. Casparagine
    4. Dglutamine
    5. Easpartic acid
    6. Fglutamic acid
    7. Gdecreases
    8. Hincreases
  5. 5Proteolysis is a form of [blank_start]covalent[blank_end] degradation where [blank_start]proteins[blank_end] are fragmented by [blank_start]proteases[blank_end]. In acidic solutions, [blank_start]aspartic acid (Asp)[blank_end] residues are the most susceptible to hydrolysis.
    1. Acovalent
    2. Bnon-covalent
    3. Cproteases
    4. Dproteins
    5. Easpartic acid (Asp)
    6. Fglutamic acid (Glu)

Information

Description
PHCY211 (Molecules) Quiz on MO17 Stability of Large Molecules, created by Mer Scott on 13/04/2018.
Author
Mer Scott
Language
English
Views
12
History
Created on 13 Apr 2018 · updated on 13 Apr 2018
Rating
No ratings yet
Rate this quiz
Rate this quiz

Feedback

What is it about?

What do you think of the new look?

How do you like it?