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MO21 Nucleic acids as therapeutics

Mer Scott 8 questions Updated 14 Apr 2018

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Questions in this quiz (8)

  1. 1Which of these biopharmaceuticals is not a nucleic acid?
    1. ADNA
    2. BRNA
    3. Cantisense oligonucleotides
    4. Dantibodies
  2. 2Gene [blank_start]replacement therapy[blank_end] is used to treat diseases caused by a mutation that stops a gene from producing a functioning product, a protein. The aim is to [blank_start]add DNA[blank_end] containing a functional version of the lost gene back into the cell. The new gene produces a [blank_start]functioning[blank_end] product at [blank_start]sufficient[blank_end] levels to replace the protein that was originally missing.
    Gene [blank_start]inhibition therapy[blank_end] is suitable for the treatment of infectious diseases, cancer and inherited disease caused by [blank_start]inappropriate[blank_end] gene activity. The aim is to [blank_start]introduce[blank_end] a gene whose product [blank_start]inhibits[blank_end] the expression of another gene.
    Gene [blank_start]cell killing therapy[blank_end] is suitable for diseases such as [blank_start]cancer[blank_end] that can be treated by destroying certain groups of cells. The aim is to insert DNA into a diseased cell that causes that cell to [blank_start]die[blank_end].
    1. Areplacement therapy
    2. Binhibition therapy
    3. Ccell killing therapy
    4. Dadd DNA
    5. Efunctioning
    6. Fsufficient
    7. Ginappropriate
    8. Hintroduce
    9. Iinhibits
    10. Jcancer
    11. Kdie
  3. 3Order these basic steps of how gene therapy works.

    [blank_start]2[blank_end]. The target cells become infected with the viral vector
    [blank_start]1[blank_end]. A vector delivers the therapeutic gene into a patient’s target cell
    [blank_start]4[blank_end]. Functional proteins are created from the therapeutic gene causing the cell to return to a normal state
    [blank_start]3[blank_end]. The vector’s genetic material is inserted into the target cell
    1. A2
    2. B1
    3. C3
    4. D4
    5. E1
    6. F2
    7. G3
    8. H4
    9. I4
    10. J1
    11. K2
    12. L3
    13. M3
    14. N1
    15. O2
    16. P4
  4. 4Which of these is not an ideal quality for a vector?
    1. AEasy and efficient to produce
    2. BTargets specific cell or tissue
    3. CProtects the DNA
    4. DImmunogenic
  5. 5There are two types of vectors: viral and non-viral.
    Viral vectors are very [blank_start]efficient[blank_end] at transfecting cells. However, there are worries about disabled viruses regaining [blank_start]virility[blank_end], [blank_start]immune[blank_end] reactions, and/or viral therapy integrating into the genome causing [blank_start]disease (cancer)[blank_end].
    Non-viral vectors mix DNA with a [blank_start]cationic[blank_end] carrier, either a [blank_start]liposome[blank_end] or a [blank_start]nanoparticle[blank_end], to form lipoplexes and nanoplexes respectively.
    1. Aefficient
    2. Bvirility
    3. Cimmune
    4. Ddisease (cancer)
    5. Ecationic
    6. Fanionic
    7. Gliposome
    8. Hnanoparticle
  6. 6Viral vector advantages:
    • [blank_start]High uptake[blank_end] into cells
    • Can be [blank_start]modified[blank_end] to target specific cells
    • They are modified so [blank_start]don’t replicate and kill[blank_end] the target cell
    Viral vector disadvantages:
    • Gene size is [blank_start]limited[blank_end]
    • Patients [blank_start]immune response[blank_end] to the virus results in poor response
    • Potential to [blank_start]integrate into genome[blank_end] causing disease (cancer)
    1. AHigh uptake
    2. Bmodified
    3. Cdon’t replicate and kill
    4. Dlimited
    5. Eimmune response
    6. Fintegrate into genome
  7. 7Non-viral vector advantages:
    • [blank_start]No immune[blank_end] response
    • [blank_start]Easily[blank_end] formulated and assembles
    • [blank_start]Cheaper[blank_end]
    • Gene size [blank_start]not limited[blank_end]
    • Cell/tissue targeting
    Non-viral vector disadvantages:
    • [blank_start]Low levels[blank_end] of gene expression (difficult to get into cell and make work)
    1. ANo immune
    2. BEasily
    3. CCheaper
    4. Dnot limited
    5. ELow levels
  8. 8Which of these is not an obstacle to success for gene therapy?
    1. AInefficient gene delivery to target cells
    2. BInadequate gene expression
    3. CUnacceptable adverse effects
    4. DAvoiding the immune response
    5. EThe cost
    6. FPotential to cure pathologies

Information

Description
PHCY211 (Molecules) Quiz on MO21 Nucleic acids as therapeutics, created by Mer Scott on 14/04/2018.
Author
Mer Scott
Language
English
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7
History
Created on 14 Apr 2018 · updated on 14 Apr 2018
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