Quiz
MO3 Drug lead discovery
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Questions in this quiz (6)
1A drug lead is something [blank_start]likely[blank_end] to be therapeutically useful. It is used as a starting point for [blank_start]chemical modifications[blank_end] to improve potency, selectivity, or pharmacokinetic parameters.
- Alikely
- Bcertain
- Cchemical modifications
- Dphysical alterations
2The higher the potency the better.
- ATrue
- BFalse
3The three broad methods to finding a lead are random screening, synthesis, and direct screening.
[blank_start]Random[blank_end] screening includes screening of synthetic compounds from in house libraries, combinatorial chemistry/parallel synthesis, screening of fragment libraries, and screening of known drugs or natural product libraries. Combinatorial chemistry [blank_start]rapidly[blank_end] generates a large number of structurally related molecules.
[blank_start]Synthesis[blank_end] is also known as "Targeted Drug Discovery" or Rational Design. The Topliss scheme can be followed to find the most appropriate aliphatic [blank_start]substituents[blank_end].
[blank_start]Direct[blank_end] Screening includes endogenous compounds, structure based drug design, virtual screening, and de novo (new) design.- ARandom
- BDirect
- CSynthesis
- Drapidly
- Esubstituents
4What is a pharmacophore?
- AThe 3D spatial arrangement of groups responsible for a defined biological activity.
- BAn atom or group whose presence is responsible for the vibrational frequency of a compound.
- CA structurally similar isomer.
5Many new drugs are created by enhancing the side effects of existing drugs.
- ATrue
- BFalse
6Drug metabolism studies are usually not worthwhile when developing drugs or removing side effects.
- ATrue
- BFalse
Information
- Description
- PHCY211 (Molecules) Quiz on MO3 Drug lead discovery, created by Mer Scott on 07/04/2018.
- Author
- Mer Scott
- Language
- English
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