Flashcards
Pharmacokinetics 2
Cards in this deck (20)
- 1What is volume of distributionmeasure of the volume of fluid that would be required to contain the total amount of drug at same conc as is measured in plasma
- 2where can drug be distributed to?remain in circ, extracellular fluid, total body water
- 3Define vdability of drug to leave circulation and enter interstitial fluid
- 4what is vd influenced bysize, plasma protein binding, endothelial cell barrier function, ion trapping, lipid solubility
- 5where is drug distribution if vd v lowplasma compartment
- 6where is drug distribution if is vd lowplasma and interstitial space
- 7what does it mean if vd is intermediatedrug has entered total body water
- 8what does it mean if vd is very highdrug concentrates in fat or binds to site in tissue in cell
- 9what are the consequences of drug-plasma protein bindingpharmacodynamics, pharmacokinetics, toxicity, interactions
- 10what are the sites of drug metabolismliver
other tissues - plasma, GI tract walls, lung and kidney - 11what happens in phase 1 of the metabolism reactionlipophilic molecules converted into polar molecules
- 12what happens in phase 2 of the metabolic reactionconjugated group added to molecule
- 13what is enterohepatic cyclingliver cells transfer drugs or conjugates to bile
hydrolysed in intestines
reabsorption - 14What are the different types of renal excretionno filtration
partial filtration
filtered then reabsorbed completely
filtered then partially reabsorbed
filtered but no reabsorption
filtered and actively secreted - 15what does extent to which they are reabsorbed depend ondrug properties and pH of urine
- 16Is secretion an active or passive process and what does it involve?Active
transporter proteins - 17Give an example of a drug that is renal excreted by more than one mechanismPenicillin - plasma protein bound so partially filtered and secreted into renal tubule
- 18what types of drugs are eliminated in renal excretion and hepatic metabolismrenal - polar drugs
hepatic - lipophilic drugs - 19which drug elimination pathways is activehepatic metabolism
- 20which form of drug elimination has a marked half life and species differencesHepatic metabolism
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- BSC Pharmacology Flashcards on Pharmacokinetics 2 , created by Teresa Richards on 01/02/2016.
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- Teresa Richards
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