Flashcards
Genome Evolution
Cards in this deck (14)
- 1Effects of Single Base ChangesCan vary- can be massive, small, or makes no difference at all
- 2GAG --> GUG in Sickle Cell AnemiaGlutamate --> Valine
- 3Mutation in S.C.ACauses loss of polar protein at position 6
- 4Promotion of non-covalent polymerisation in S.C.AIs what causes Hb agglutination and sickle shaped cells
- 5S.I of Whale & Human Hb17% - but same function
- 6Gene loss in bacteriaBacteria can excise non-functioning DNA
- 7Gene inactivationWhere mutations effect promoter regions
- 8Small Insertions/DeletionAllows specificity for different substrates- leads to related protein types
- 9Whole domains can be inserted as long as...the core remains undamaged and able to perform it's function
- 10Cause of ParaloguesGene Duplication
- 11Limit of replicationWhole genomes/chromosomes
- 12Movement of replicated genesTo other chromosomes or fusion with other genes
- 13Gene RearrangementIncorrect duplication can lead to rearrangement of domains/fusion proteins
- 14% of domain pairs in the same order90- gene rearrangement is difficult to successfully
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- Structural Basis for Biological Function (Basics) Flashcards on Genome Evolution, created by gina_evans0312 on 14/12/2013.
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- gina_evans0312
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