Glycogen Phosphorylase Structure (Without Phosphorylation)

Glycogen Phosphorylase Structure (Without Phosphorylation)

1. T Form

   • Inactive- Active site it buried within protein
     • Caused by
       • High ATP
       • High glucose-6-phosphate
       • Glucose (In the liver)

2. R Form

   • Active- Active site is acessable to glycogen
     • Caused by
       • AMP
       • Pi
       • Phosphorylation

3. Interface domain

   • Contains allosteric effector site
     • Where ATP/AMP binds

4. Active Site

   • Found in deep groove to prevent water entering
     • Entrance of water causes hydrolysis instead of phosphorylysis
     • Made of
       • Glycogen Storage
       • Interface
       • And C Terminus Domains
     • This deep groove is what causes the steric hinderence during cleavage