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MO11 Biologics: Proteins and peptides

Mer Scott 12 questions

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Questions in this quiz (12)

  1. 1A biologic is the same as a biopharmaceutical.
    1. ATrue
    2. BFalse
  2. 2A biologic is any drug product [blank_start]manufactured[blank_end] in, extracted from, or semi-synthesized from [blank_start]biological[blank_end] sources. This includes [blank_start]vaccines[blank_end], blood and blood products, allergenics, cells, gene therapy, tissues and recombinant therapeutic proteins.
    1. Amanufactured
    2. Bbiological
    3. Cvaccines
  3. 3Choose the incorrect statement.
    1. AHuman sourced therapeutic proteins have safety issues (pathogens) and availability issues (greater demand than supply)
    2. BInsulin from cattle and pigs had issues with immunogenicity, ethical and cultural beliefs
    3. CInsulin from bacteria has issues with availability (greater demand than supply)
  4. 4Order the steps of making recombinant insulin in bacteria from 1-5

    [blank_start]4[blank_end]. An inducer signals protein synthesis
    [blank_start]5[blank_end]. Protein produced and purified
    [blank_start]1[blank_end]. Plasmid is "cut" with enzyme
    [blank_start]3[blank_end]. Plasmid is inserted into bacteria E. coli
    [blank_start]2[blank_end]. Human gene for insulin is cloned into plasmid
    1. A1
    2. B2
    3. C3
    4. D4
    5. E5
    6. F5
    7. G4
    8. H3
    9. I2
    10. J1
    11. K1
    12. L2
    13. M3
    14. N4
    15. O5
    16. P3
    17. Q1
    18. R2
    19. S4
    20. T5
    21. U2
    22. V3
    23. W1
    24. X4
    25. Y5
  5. 5Choose the incorrect statement.
    1. AThe advantages of bacteria as hosts is that they are inexpensive, grow rapidly, have high yield, and are virus free.
    2. BThe disadvantages of bacteria as hosts is that they cannot glycosylate or form disulfide bonds.
    3. CThe advantages of yeast as a host is that is is inexpensive, rapidly grows, is virus free and has a high yield.
    4. DThe disadvantage of yeast is hyperglycosylation.
    5. EAn advantage of mammal cells is humanised glycosylation, as well as proper folding, but some disadvantages are the expensive cost, low yield, and viral contamination.
  6. 6The advantages of recombinant proteins are they are [blank_start]more[blank_end] efficient and [blank_start]cheaper[blank_end] to make, and you can make a [blank_start]high[blank_end] quantity. You can also modify them, for example to be more [blank_start]fast[blank_end] acting. There's also a reduced risk that [blank_start]pathogens[blank_end] from animals can be transferred.
    1. Amore
    2. Bcheaper
    3. Chigh
    4. Dlow
    5. Eless
    6. Ffast
    7. Gpathogens
  7. 7Which of these is not a disadvantage of mammalian hosts?
    1. ALong time to generate and validate animal
    2. BGene may affect animal
    3. CProteins cannot be harvested until lactation begins
    4. DPoor yield of protein
  8. 8Advantages of proteins over small molecules:
    - [blank_start]Faster[blank_end] FDA approval time
    - Proteins a lot [blank_start]more[blank_end] specific
    - Therefore have [blank_start]less[blank_end] potential for side effects
    - Less likely to produce an [blank_start]immune response[blank_end]
    - In diseases due to gene mutation, proteins can be [blank_start]replacement therapy[blank_end]
    1. AFaster
    2. Bmore
    3. Cless
    4. Dimmune response
    5. Ereplacement therapy
  9. 9Classification of protein therapeutics:
    Group 1 — [blank_start]with enzymatic or regulatory activity.[blank_end]
    Group 2 — [blank_start]with special targeting activity.[blank_end]
    Group 3 — [blank_start]protein vaccines.[blank_end]
    Group 4 — [blank_start]protein diagnostics.[blank_end]
    1. Awith enzymatic or regulatory activity.
    2. Bwith special targeting activity.
    3. Cprotein vaccines.
    4. Dprotein diagnostics.
  10. 10Insulin and botox are both classed inn Group 1 of protein therapeutics.
    1. ATrue
    2. BFalse

Information

Description
PHCY211 (Molecules) Quiz on MO11 Biologics: Proteins and peptides, created by Mer Scott on 10/04/2018.
Author
Mer Scott
Language
English
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