Quiz
MO27 Enzymes as Drug Targets
This quiz has question types that open in the usual player.
Questions in this quiz (3)
1Which of these is not a function of enzymes?
- AProvides hydrophobic environment - desolvated
- BProvides acid/base catalysis
- CWeakens bonds
- DBrings reactants together, correctly positioned
- EProvides a reaction surface (active site)
- FProvides a hydrophilic environment - solvated
2Which of these is not a good drug target for reducing growth of or killing pathogens?
- ANeuraminidase
- BTranspeptidase
- CHIV protease
- DCyclooxygenase
3Types of competitors:
1. Competitive inhibitors — bind to the [blank_start]same active site[blank_end], bind [blank_start]reversibly[blank_end], “If concentration of substrate increases it [blank_start]competes more effectively with[blank_end] the drug
1.a. Transition-state inhibitors (competitive) — inhibitor that [blank_start]mimics[blank_end] the “transition state” of an enzyme catalysed reaction, need to understand the [blank_start]mechanism[blank_end] of catalysis (i.e. need to know intermediates of the reaction) to design, inhibitor should bind [blank_start]more strongly[blank_end] than either substrate or product
2. Allosteric non-competitive inhibitors — inhibitors bind [blank_start]reversibly or irreversibly[blank_end] to the allosteric site, some enzymes can be [blank_start]naturally[blank_end] regulated by allosteric binding, can cause an [blank_start]induced[blank_end] fit or [blank_start]conformational (shape)[blank_end] change in the active site and [blank_start]reduce[blank_end] substrate affinity for it
3. Allosteric un-competitive inhibitors — not common, bind reversibly to an enzyme when the substrate is [blank_start]already[blank_end] bound (binds to the Enzyme-Substrate (ES) complex), increasing substrate concentration [blank_start]will not[blank_end] overcome inhibition
4. Suicide inhibitors — Kill the enzyme- Asame active site
- Breversibly
- Ccompetes more effectively with
- Dmimics
- Emechanism
- Fmore strongly
- Greversibly or irreversibly
- Hnaturally
- Iinduced
- Jconformational (shape)
- Kreduce
- Lalready
- Mwill not
Information
- Description
- PHCY211 (Molecules) Quiz on MO27 Enzymes as Drug Targets, created by Mer Scott on 15/04/2018.
- Author
- Mer Scott
- Language
- English
- Views
- 6
- Tags
- Rating
- No ratings yet Rate this quiz