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MO15 Quality Control I

Mer Scott 8 questions

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Questions in this quiz (8)

  1. 1Within a [blank_start]pharmacopoeia[blank_end], each product has a [blank_start]monograph[blank_end] containing information and tests used to define its quality. The monograph provides information to satisfy 3 main objectives:
    1. verification of [blank_start]identity[blank_end]
    2. [blank_start]homogeneity[blank_end] (to ensure absence of specified impurities)
    3. [blank_start]purity[blank_end] (using assay methods)
    1. Apharmacopoeia
    2. Bmonograph
    3. Cidentity
    4. Dhomogeneity
    5. Epurity
  2. 2Which test is not as useful to identify drugs?
    1. AProton (1H) or carbon (13C) NMR spectroscopy
    2. BMass spectrometry (MS)
    3. CInfrared Spectroscopy (IR)
    4. DUV-Vis spectroscopy
  3. 3Testing for impurities assures [blank_start]homogeneity[blank_end]. These are also called limit tests, and include:
    - Testing for residual solvents — using [blank_start]gas chromatography[blank_end]
    - Testing for inorganic compounds — measured by [blank_start]“residue on ignition”[blank_end]
    - Testing for heavy metals — by reaction with [blank_start]thioacetamideglycerin TS (test solution)[blank_end]
    1. Ahomogeneity
    2. Bpurity
    3. Cgas chromatography
    4. D“residue on ignition”
    5. Ethioacetamideglycerin TS (test solution)
  4. 4Which of these is not an assay method for purity?
    1. ATitration
    2. BUV-Vis spectrophotometric assay
    3. CHigh Performance Liquid Chromatography (HPLC)
    4. DThin-layer chromatography (TLC)
  5. 5Absorption of IR radiation by molecules (including drugs) result in [blank_start]vibrations[blank_end] of the chemical bonds. The simplest type of vibration is [blank_start]stretching[blank_end]. The frequency of oscillation ([blank_start]v[blank_end]) is governed by:
    1) The mass of the two atoms ([blank_start]m1 and m2[blank_end])
    2) The bond order (bond strength [[blank_start]springiness - K[blank_end]]), which is determined by the [blank_start]hybridisation[blank_end] of the atoms constituting the bond.
    1. Avibrations
    2. Bstretching
    3. Cv
    4. Dm1 and m2
    5. Espringiness - K
    6. Fhybridisation
  6. 6There is no IR absorption by N2 or O2.
    1. ATrue
    2. BFalse
  7. 7Which of these is not an effect of conjugation?
    1. AIncreased resonance
    2. BDouble bond is shorter and weaker than expected
    3. CDecreased K, therefore decreased wavenumber
  8. 8Halogens shift bands to lower frequencies through induction.
    1. ATrue
    2. BFalse

Information

Description
PHCY211 (Molecules) Quiz on MO15 Quality Control I, created by Mer Scott on 13/04/2018.
Author
Mer Scott
Language
English
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