Quiz
MO24 ADME - Absorption
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Questions in this quiz (8)
1Factors Affecting Drug Absorption:
1. Route of [blank_start]Administration[blank_end]: the surface area, [blank_start]blood flow[blank_end] at administration site, contact time, and [blank_start]first pass[blank_end] effect
2. [blank_start]Properties[blank_end] of the Drug: ability to [blank_start]breach[blank_end] biological barriers, chemical structure, lipid [blank_start]solubility[blank_end], molecular weight, and [blank_start]ionization[blank_end]
3. Patient Factors: gastric [blank_start]pH[blank_end] and gastrointestinal [blank_start]motility[blank_end]- AAdministration
- Bblood flow
- Cfirst pass
- DProperties
- Ebreach
- Fsolubility
- Gionisation
- HpH
- Imotility
2Lipinksi's rule of fives is a strict set of rules for if a drug can breach membranes.
- ATrue
- BFalse
3Lipinski defined the boundaries of good absorption potential by demonstrating that poor permeability is produced by:
– More than [blank_start]5[blank_end] H-bond donors (sum of OHs and NHs)
– More than [blank_start]10[blank_end] H-bond acceptors (sum of Ns and Os)
– Molecular weight over [blank_start]500[blank_end]
– Poor dissolution by [blank_start]log P > 5[blank_end]- A5
- B10
- C500
- Dlog P > 5
- Elog P < 5
4Choose the incorrect statement about log P and drug transport.
- APartition coefficients influence the way drugs reach the site of action from the site of administration.
- BVery water-soluble drugs may be unable to cross cell membranes and reach organs rich in lipids such as brain.
- CVery hydrophilic drugs may be trapped in fat tissue
5Absorption from the small intestine is much greater than absorption from stomach when only considering surface area.
- ATrue
- BFalse
6The greater the lipophilicity of the drug, the slower it is absorbed.
- ATrue
- BFalse
7Acidification of urine promotes reabsorption of [blank_start]weak acids[blank_end] and excretion of [blank_start]weak bases[blank_end]. Alkalinisation of urine promotes [blank_start]reabsorption[blank_end] of weak bases and [blank_start]excretion[blank_end] of weak acids.
- Aweak acids
- Breabsorption
- Cexcretion
- Dweak bases
8In general, the greater the fraction of a drug ionised in urine, the longer the half life of the drug and vice versa.
- ATrue
- BFalse
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- Description
- PHCY211 (Molecules) Quiz on MO24 ADME - Absorption, created by Mer Scott on 14/04/2018.
- Author
- Mer Scott
- Language
- English
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