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lecture 1

• The goal of a host:
• use diverse strategies to keep the host safe from infectious organisms.
• To have a host hurt you:
• penetrate: get inside
• adhere: stick and adhere
• thrive: find the right nutrients and conditions from growth. minimum of these three must happen to cause infection.
• Where are they going to attack to get inside? Ways of microbial entry.
• skin
• lungs
• GI tract
• oral/gut
• The defenses from the host are either
• innate
• adaptive

Innate Immunity

• What you are born with, just waiting to protect you.
• Physical barriers: Most important barriers during infection. Skin- 99.99% defensive, lactic acid production. Mucous membranes- prevent from entry, getting into tissues. Fluids- mucous. Prevents pathogen adhesion on membranes.
• physiological barriers:
• inflammation

Bug Attacks

• These bugs will produce their own digestive enzymes. which will digest certain collagen etc.
• Adhesions, specialized molecules that will find and bind.
• Motility, swim, move to propel through mucous and fluids, barriers.
• colonization: colonize the host. It will land, stick and grow. Replication will take place; become genetically identical from original. Creates a colony, mutations are rare.
• Virulence Factors: Helps for survival. Made to do damage to the host.

Slide 4