Flashcards
The Citric Acid Cycle
Cards in this deck (15)
- 1What factors inhibit Pyruvte Dehyrodgenase?High levels of NADH or NAD, High levels of Acetyl Co-A, High levels of ATP/ADP.
- 2Anaplerosis:Series of enzymatic reactions that replenish intermediates.
- 3What factors stimulate Pyruvate Dehydrogenase?Non-Acetylated CoA and NAD+.
- 4Cataplerosis:Series of enzymatic reactions that remove intermediates.
- 5Does TCA Intermediate availability play any role in causing fatigue?No. TCA intermediates never fall below a certain point thus not a cause of fatigue.
- 6What does the Alanine Aminotransferase Reaction do?It generates TCA intermediates at the onset of exercise.
- 7TCA cycle is regulated by:Intermediate availability. Acetyl CoA availability. The enzymes are controlled by Ca, ATP and ADP.
- 8What do we breakdown and form in TCA cycle??We break down Pyruvate into energy rich NADH and FADH (for breakdown in ETC)
- 9Where does the TCA take place?Mitochondrial Matrix of the Cell
- 10What do we get from TCA?3 NADH, 1 FADH, 1 GTP and 2 CO2
- 11What is GTP?Guanosine Triphosphate. It helps us make ATP.
It costs 2 GTP per 8 cycles of the TCA. Thus in 8 cycles we get 6 ATP. - 12Does Pyruvate have to be broken down before entering the TCA cycle?Yes- It is broken down to Acetyl-CoA by Pyruvate Dehydrogenase.
- 13Intermediates of TCA:Acetyl CoA, Citrate, Isocitrate, Alpha Ketoglutarate, Succinyl CoA, Succinate, Fumarate, Malate, Oxaloacetate.
- 14Enzymes of TCA Cycle:Citrate Synthase, Aconitase Isocitrate Dehydrogenase, Alpha Ketoglutarate Dehydrogenase, Succinyl CoA Synthetase, Succinate Dehydrogenase, Fumarase, Malate Dehydrogenase.
- 15What is the process?Through a series of reactions we cleave 2 carbon atoms from a 6 carbon atom substance. This is Citrate- formed from 2 carbon atom Acetyl CoA and 4 carbon atom Oxaloacetate)
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- Exercise Metabolism- Term 1 (TCA Cycle) Flashcards on The Citric Acid Cycle, created by Mark Arsenal on 15/04/2013.
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- Mark Arsenal
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