T Cells

T Cells

1. Th cells

   • Maturation of B cells
     • Plasma Cells
     • Memory B cells
   • CD4
     • activated by MHC class II
       • APC's
       • Rapid division and cytokine secretion
   • Subtypes
     • Th1
     • Th2
     • Th3
     • Th17
     • Tfh

2. Treg cells

   • Control T cell mediated immunity
   • Degrade autoreactive T cell
     • Escape selection in thymus
   • Naturally occuring
     • CD4CD25FoxP3
       • FoxP3 mutation
         • Autoimmune disease
   • Adaptive
     • Th3

3. Tc cells

   • Destroys infected or cancer cells
   • Transplant rejection
   • CD8
   • MHC class II
     • All nucleated cells
   • Inactivated by Treg cells
     • IL-10
     • Adenosine
     • Prevent autoimmune state

4. Memory T cells

   • Central memory T cells (Tcm)
   • Effector memory T cells (Tem)
   • Cognate antigen
     • rapid expansion
     • Effector T cell
   • CD4 OR CD8
   • Express CD45RO

5. NKT cells

   • Bridge adaptive and innate immune response