Flashcards
Fungi Introduction
Cards in this deck (20)
- 1How does the way yeast and mold REPRODUCE differ?Yeast: budding
MOLD: branching and extension of length - 2How is the structure of yeast and mold different?Yeast: smooth round, flat colonies
MOLD: filamentous, made of tubular structures and HYPAHE, fuzzy borders - 3Are yeast and mold both fungi?YES!
- 4*****A _____ fungus grows as a _____ in the host at body temperature but as a _____ in the lab at room temperature.DIMORPHIC
Yeast (body)
Mold (room) - 5***Name 5 medically relevant dimorphic fungiBlastomycosis
Coccidiodomycosis
Paracoccidioidomycosis
Histoplasmosis
Sporotrichosis - 6***What are the main components of a fungal cell?Cell wall contains:
CHITIN
GLUCANS
MANNOPROTEINS
Plasma Membrane contains:
Ergosterol (unique sterol)
*target of some antifungals - 7Fungi cells are most similar to _____ cells.Plant (w/o PT)
- 8What are the 3 cellular targets for antifungal therapies?Cell Wall - Glucans
Plasma Membrane - Ergosterol
Nuclear - DNA and RNA - 9*** What are the 4 classes of fungal disease?1. Superficial
2. Subcutaneous
3. Opportunistic and immunosuppressed
4. Endemic - 10****What are the 3 main risk factors for fungal infection?1. Immunosuppression
2. extended antibiotic use
3. LINES (IVs, Catheders etc) - 11****What are the 6 tests that can be done to diagnose fungal infections?- direct microscopy (histo)
- stains
- culture
- serology
- antigen detection
- nucleic acid testing - 12What are the 5 types of stains used to stain fungi?Grocott-Gomori
H&E
Mayer's mucicarmine
Masson-Fontana
Periodic Acid Schiff - 13What is the Galactomannan test?Enzyme immunoassay that can be used in lung and serum samples to diagnose invasive aspergillosis
- 14Describe the epidemiology of Aspergillosis.- highest in stem cell and solid organ transplant patients
- also likely in immunocompromised or relapsing malignancies - 15What are the 3 (general) clinical manifestations of Aspergillosis?1. Allergic
2. Colonization
3. Invasive - 16What is the ABPA response to aspergillosis?Allergic BronchoPulmonary Aspergillosis
(long term allergic rxn)
- results in pneumonia and impacted mucous in the bronchi - 17What is a fungus ball?Colonization due to aspergillosis
- huge mass of hyphae grow in a lung cavity - 18What is IPA?Invasive Pulmonary Aspergillosis
- prolonged neutropenia = risk factor
- inhale condida - 19If someone has IPA, what do you see on the CT scan?dense, nodular infiltrates
HALO around nodular regions - 20***How can aspergillosis be treated?Allergic: steroids and itraconazole
Colonization: surgery
Invasive: Voriconazole, Amph B OR echinocandons, posaconazole, itraconazole
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- Foundations (DMED 511) - Final Prep (Fungi) Flashcards on Fungi Introduction, created by Manisha BHARADIA on 31/10/2018.
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- Manisha BHARADIA
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