Flashcards
Cell Biology : Glycolysis and Krebs Cycle
Cards in this deck (15)
- 1What are the regulatory points in Glycolysis?Steps 1, 3 and 10.
- hexokinase
- phosphofructokinase
- pyruvate kinase - 2What is hexokinase regulated by?Glucose-6-phosphate
- 3What is PFK-1 regulated by?Inhibited by ATP.
Action reversed by AMP - 4What is pyruvate kinase regulated by?Inhibited by ATP and Acetyl-coA
Activated by fructose-1,6 bisphosphate (step 4) - 5What happens in tarui disease?The cells cannot convert fructose 6-phosphate to fructose 1,6-bisphosphate (step 3) therefore there is a build up of glycogen in muscles.
- 6What happens if there is a deficiency of pyruvate kinase?Less ATP production, RBC short half life and lyse easily
- 7Under anaerobic conditions, what is pyruvate converted to?Lactate
- 8What activates the PDH complex?AMP, NAD+, coA
- 9What inhibits PDH activity?ATP, NADH, Acetyl CoA
- 10Do high concentrations of the end products (ATP and NADH) stimulate the cycle?No they inhibit it. Substrates like NAD+ and ADP stimulate the cycle
- 11How does sodium fluoroacetate affect the Krebs cycle?It inhibits formation of isocitrate therefore causing a build of of citric acid
- 12What are some of the effects of acute exposure and serious poisoning of sodium fluoroacetate?Nausea vomiting and diarrhoea. Serious poisoning can cause seizures, comas, respiratory depression among other cardiac symptoms
- 13What is Beri Beri and how does it affect the Krebs cycle?Vitamin B1 (thiamine) deficiency. Thiamine phosphate is required as a part of pyruvate dehydrogenase and α-ketoglutarate dehydrogenase. It results to high levels of pyruvate and α-ketoglutarate in blood.
- 14What type of symptoms is Beri Beri characterised by?Neurological and cardiac
- 15What kind of symptoms would you expect from Beri Beri?Limb pain, weak muscles, distorted skin sensation. May be enlargement of heart with low cardiac output
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- Cell Biology Flashcards on Cell Biology : Glycolysis and Krebs Cycle, created by savaniprachi on 30/05/2014.
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