Gastrointestinal Pathology

Gastrointestinal Pathology

1. Gastritis

   • Cronic
     • Long term use of NSAID's
       • Heliobactor pylon
         • Pernicious Anemia
           • Radiation/chemotherapy
   • Acute
     • Erosive
       • Superficial
         • deep
           • Hemorrhagic
       • Causes
         • NSAID's
         • Ischemia
         • Alcohol
         • Stress
     • Nonerosive
       • Heliobactor Pylon
         • Causes
           • Bacterial
           • Viral etc
         • Can lead to cronic
     • Pangastritis (whole stomach)
     • Antril Gastritis (part of)
   • Inflammatory changes in gastric mucosa

2. Polyps

   • 1% become malignant
     • BUT show a predisposition to Colon cancer
       • Can be inherited- Polyposis Syndrome
   • Benign
   • Hyperplastic Polyps
     • Found mostly in the Rectosigmoid region
       • Those found in the Sigmoid Colon have potential to become malignant
         • In the presence of Hyperplastic Polyposis Syndrom
   • Adenomas
     • Found anywhere
       • Risk of malignancy depends on size and histology
   • Polyposis syndrome
     • Many hereditary causes

3. Colon Cancer

   • Causes
     • Smoking
     • Alcohol
     • Obesity
     • Crohn's Disease
   • 2nd Highest in Men in Malta
   • Matastisies
     • Liver

4. Crohn's Disease

   • Affects mainly the illium but can affect anywhere in the tract
   • Causes
     • Family history
     • Smoking

5. Gastric(stomach) Cancer

   • Causes
     • Heliobactor Pylon
       • Smoking
   • Adenocarcinoma