Flashcards
OCB02-1012-Signalling pathways in tooth development
Flashcards do conjunto (13)
- 1Is tooth initiation controlled by the oral ectoderm or the mesenchyme cells?Oral ectoderm
- 2What gene is expressed in the mesenchyme at the initiation of tooth formation?PAX-9
- 3What are the 3 methods of cell signals communicating?1. Diffusion
2. Gap junction
3. Direct contact - 4How do signals impact protein synthesis change?1. Receptors bind signal molecules
2. Signal transduction pathway wherein cytoplasmic protein carries signal to nucleus
3. Change in transcription factors change gene expression
4. Protein synthesis change - 5When does patterning of the dentition occur?Before initiation
- 6In tooth formation what information is contained in the epithelium, and what is contained in the mesenchyme?Epithelium contains signals to make a tooth, mesenchyme determines which TYPE of tooth (homeobox code)
- 7What is the signalling pathway for an incisor to develop?1. BMP-->Incisor mesenchyme
2. Incisor mesenchyme sends MSX-1/2 - 8What is the signalling pathway for an molar to develop?1. FGF-->molar mesenchyme
2. Molar mesenchyme sends DIX-1/2 - 9What does SHH signalling during initiation do?Determines SITES of tooth development by causing ectopic tooth thickening in epithelium so it can become tooth bud
- 10What prevents SHH from leaving the epithelium and initiating tooth formation elsewhere?Wnt7b at dental epithelium boundary
- 11What does MSX1/PAX9 mutations lead to?Partial tooth agenesis in humans, full in rats
- 12What initiates cap formation as well as PEK formation?The BMP signalling pathway
- 13What is the BMP signalling pathway?1. BMP4 from epithelium activates MSX1 in mesenchyme
2. MSX1+PAX9 in mesenchyme activates BMP4 which diffuses into bud epithelium
3. Leads to formation of cap+SHH-->PEK formation
Informações
- Descrição
- LOs are to: Recall different types of cell signalling Understand the basic principles of signal transduction systems. Describe recombination experiments performed to identify the source of inductive signals. Give examples of different signalling pathways used during tooth development and their role at specific stages of tooth development.
- Criado por
- Evian Chai
- Visualizações
- 45
- Tags
- Avaliação