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MO26 Drug Transport

Mer Scott 3 questions

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Questions in this quiz (3)

  1. 1Influx Transporters:
    – [blank_start]Solute carrier (SLC)[blank_end] superfamily
    – Facilitated transport of drug [blank_start]into cell[blank_end]
    – [blank_start]High[blank_end] substrate selectivity
    – Xenobiotic/drug structural [blank_start]similarity[blank_end] to endogenous substrate eg. 5-fluorouracil uses uracil active transport system
    Efflux Transporters:
    – [blank_start]ATP-binding cassette (ABC)[blank_end] superfamily
    – ATP energy-dependent transport to pump drug [blank_start]out of cell[blank_end]
    – [blank_start]Low[blank_end] substrate selectivity
    – Function to [blank_start]protect[blank_end] the cell against [blank_start]hydrophobic[blank_end] xenobiotic molecules
    1. ASolute carrier (SLC)
    2. BATP-binding cassette (ABC)
    3. Cinto cell
    4. Dout of cell
    5. EHigh
    6. FLow
    7. Gsimilarity
    8. Hprotect
    9. Ihydrophobic
  2. 2Which of these is not a method to overcome multidrug resistance?
    1. AAdministration of inhibited drug with a co-drug to improve drug uptake
    2. BAdministration of inhibited drug with a polycationic peptide to avoid drug efflux
    3. CAdministration of inhibited drug with a co-solvent to improve drug uptake
  3. 3ΔLog P can be used for estimating [blank_start]lipophilicity[blank_end] of drugs using the equation ΔLog P = [blank_start]Log Poct[blank_end] - [blank_start]Log Pchex[blank_end].
    Log Poct refers to [blank_start]n-Octanol[blank_end], which supports H-bonding. Log P can [blank_start]over-represent[blank_end] the membrane crossing [blank_start]ability[blank_end] of compounds capable of forming [blank_start]H-bonds[blank_end] eg. compounds containing amides and carboxylic acid groups. Use of a hydrocarbon solvent like [blank_start]cyclohexane[blank_end] (Log Pchex) can [blank_start]discriminate[blank_end] these compounds. It is good for designing drugs which can cross the [blank_start]BBB[blank_end] and useful for studying brain penetration and designing [blank_start]CNS active[blank_end] drugs.
    1. Alipophilicity
    2. BLog Poct
    3. CLog Pchex
    4. Dn-Octanol
    5. Eover-represent
    6. FH-bonds
    7. Gability
    8. Hcyclohexane
    9. Idiscriminate
    10. JBBB
    11. KCNS active

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Description
PHCY211 (Molecules) Quiz on MO26 Drug Transport , created by Mer Scott on 15/04/2018.
Author
Mer Scott
Language
English
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