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BMS03-1013- Cell Signalling 2
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- 1What are the three types of ionotropic receptors? What does each do?1. Trimeric (uses K+/Ca2+/Na+)
Depolarises
2. Tetrameric (Glutamate/AMPA)
Depolarises
3. Pentameric (NACHR/Glycine/GABA)
Depolarises+Hyperpolarises - 2What normally keeps ionotropic receptors closed?Hydrophobic AA Chain
- 3What happens when a ligand binds to an ionotropic receptor?Conformational change as hydrophilic parts of pore orient inwards to let pore in
- 4Where is the tyrosine kinase receptor located and what is its structure?1. Located on the membrane
2. Transmembrane receptor with ligand binding site and 3 Tyr on bottom - 5What first happens when a ligand binds to a monomer of TKR?Dimerisation, 2 TKR joined by disulphide bonds
- 6How is the dimerised TKR activated?Autophosphorylation
- 7What does activated TKR do?Recruits and activates RAS activating protein, which leads to GDP-->GTP on RAS
- 8What does activated RAS do?activates MAP kinase signalling, wherein activated MAP Kinase kinase kinase phosphorylated to MAP Kinase
- 9What does MAP Kinase change?Protein phosphorylation/gene transcription, leading to cell signalling
- 10What is an example of TKR?Insulin
- 11What does insulin do?1. Increase glucose/fat/protein formation
2. Increase glucose uptake
3. Increase glucose utilisation
4. Increase glycogen formation - 12Where are DNA Binding/nuclear receptors located?In the cell
- 13What is the structure of DNA Binding/Nuclear receptors?Has
1. Ligand binding site
2. Zinc fingers for DNA binding
3. Coactivator region - 14What occurs when a hydrophobic cell enters a molecule and binds to a nucleur receptor?Dimerization
- 15What occurs following the dimerisation of a nuclear receptor?Translocation of the receptor into the nucleus, where it binds to regulatory parts of DNA
- 16What do nuclear receptors impact?mRNA transcription and changes in protein synthesis
- 17What are examples of nuclear receptors?Steroid/thyroid hormone/Vit D/Glucocorticoid/Retinoic Acid/retinoid/Sex hormone receptors
Informationen
- Beschreibung
- function and action of receptor tyrosine kinase signalling. main features of the insulin receptor and the function of the tyrosine kinase domain. Outline a physiological/metabolic process regulated by a tyrosine kinase-dependent mechanism. Outline the function and action of ligand-gated receptors and ion channels. Outline a physiological process regulated by ion channels. Describe the function and action of steroid hormone receptors. Outline a steroid hormone physiological process
- Erstellt von
- Evian Chai
- Aufrufe
- 46
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