Flashcards
Mitochondrial Targeting and Transport
Cards in this deck (17)
- 1Length of Mitochondria target sequence10-60 residues
- 2Residues in Mitochondria target sequenceAlternate- +ve and hydrophobic
- 3Structure of Mitochondrial Target SequenceForms an ampipathic helix- may or may no be cleavable
- 4Import Pore- TOM404-8 monomers that form the pore
- 5Import Pore- TOM22Receptor for unfolded protein, and rebinds polypeptide when it's passed the pore to prevent it aggregating
- 6Import Pore- TOM20/70Associated receptors
- 7Translationally Coupled- TOM20Recognizes ampipathic helix of unfolded protein
- 8Translationally Coupled- Chain of proteinsTOM20-TOM22-TOM5-TOM40
- 9(Yeast) Post Translational- MSFMitochondrial Import Stimulating Factor
- 10MSF binds...Once protein has been folded by ribosomal (yeast) or cytoplasmic (mammals) chaperones
- 11At pore, MSF interacts withTOM70, which recognises it
- 12Carrier proteinsCarry other molecules in and out of mitochondria, and also pass through pore
- 13TIM23/27Forms import pore
- 14N-terminus of TIM23Recognises MSF
- 15TIM44Recruits matrix Hsp70 (and Hsp40/NEF) to TIM complex to fold it as it enters the mitochondria
- 16Lateral GateAllows protein to enter mitochondrial matrix
- 17Mitochondrial Processing PeptideRemoves mitochondrial targeting factor (cleaves at penultimate residue)
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- Structural Basis for Biological Function (Protein Translocation) Flashcards on Mitochondrial Targeting and Transport, created by gina_evans0312 on 21/12/2013.
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- gina_evans0312
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