530433
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
almost 12 years ago
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| Question | Answer |
| Culture Media | Can grow on nutrient but blood is better |
| S.Aureus on blood agar | Pinhole colones coloured yellow (S.Aureus is haemolytic) |
| Selecting S.Aureus (Agar) | MSA- Mannitol Salt Agar (S.Aureus is salt tolerant) |
| Method of MSA | Mannitol is fermented, which is shown by the indicator turning yellow |
| Blood-Coagulase Test | S.Aureus can convert Fibrinogen -> Fibrin in of plasma, causing clumping |
| Agar-DNAse Test | S.Aureus can clear a DNA-impregnated agar plate (this can be made clearer using Mannitol/Indicator) |
| Mild S.Aureus Infections | Skin, soft tissue, food poisoning |
| Sever S.Aureus infections | Bone/blood/organ infections, toxic shock |
| S.Aureus Environment | Usually endogeous, can be exogenous |
| S.Aureus Mode of Transmission | Injestion, Aeresol, contact |
| S.Aureus- Host Factors | Age, Suppressed immune system |
| S.Aureus- MSCRAMMS | Microbial Surface Components Recognizing Adhesive Matrix Molecule |
| S.Aureus- Role of MSCRAMMS | Recognise and bind to a specific host molecule |
| S.Aureus- Uniqueness of MSCRAMM's | S.Aureus can bind to multiple host molecules |
| S.Aureus- Metastasis | Refers to its ability to travel in blood and infect other tissues |
| S.Aureus- Enzmyes | Produces a wide variety |
| S.Aureus Enzmyes- Coagulase | Forms a fibrin barrier around the bacteria |
| S.Aureus Enzmyes- Lipases | Bind to/destroy host tissues |
| S.Aureus Enzmyes- Protein A | Binds to blood Ib's and masks bacterium |
| S.Aureus Toxins- PVL | Panton Valentine Leucocidin |
| S.Aureus Toxins- Role of PVL | Forms pores in leukocytes to release inflammatory mediators, killing them and damaging tissues |
| S.Aureus Toxins- Enterotoxin | Works in intestine (action unknown) causing vomiting |
| S.Aureus Toxins- Enterotoxin Strains | A-E & G-J (A most common) Works as a super-antigen |
| S.Aureus Toxins- TSST1 | Toxic Shock Syndrome Toxin 1 |
| S.Aureus Toxins- Role of TSST1 | Fever, rash, loss of skin & shock like symptoms |
| S.Aureus Toxins- Release of TSST1 | Inserted into blood by bacteria (bacteria themselves not present) |
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