Flashcards

Introduction of Adaptive Immune Response

Anuarruddin Azmilumur English 15 cards

Cards in this deck (15)

1Adaptive Immune Response- Specific
- Fully activated only after infections
- Response magnitude higher in the second infections
- Memory stored
2Development of LymphocytesT cells
B cells
3Antigen-independent maturation sitesT cells in thymus
B cells in bone marrow
4Function of surface markers or receptorsi. Bind to receptors on other cells
ii. Bind to antigen
iii. Transmit and receive messages
5Common receptor moleculesi. Major histocompability complex (MHC)
ii. Cluster of differentiation (CD)
iii. Antigen-specific receptors
6Three class of MHCi. Class I - expressed on all nucleated cells
ii. Class II - on APCs ; dendritic cell, macrophages, B cell
iii. Class III - on protein associated with complement system
7CD molecules sites of binding
8Antigen-specific receptors & Clonal deletion
9Presentation of antigenAntigenicity based on:
i. Size
ii. Complexity
iii. Foreignness
10Role of antigen-presenting cell
11Receptors on T cell and B cellT cell receptor (TCR) - supported by co-receptor such as CD4 CD8
B cell - immunoglobulins or antibody
Class - IgG IgA IgM IgE IgD
12T cell activation
13Function of T cell differentiationsT helper cell - stimulate or activate other cells, including macrophages, B cell, cytotoxic cell
Memory T cell - store immunological memory
Regulatory T cell - regulate other cells to prevent excessive inflammation & autoimmune
Cytotoxic cell - infected host cell, cancerous host cell, foreign cells. involve secretion of granzyme & perforins
14B cell activation
15Role of B cell differentiationMemory cell - store immunological memory
Regulatory B cell - regulate to prevent excessive inflammation & autoimmune
Plasma B cell - launch antibodies (opsonisation, neutralisation, agglutination, )